从益智果中分离得到两个新的倍半萜类化合物。

IF 1.9 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-02-01 DOI:10.1080/14786419.2023.2272282

Weirong Bai , Tuanjie Wang , Xiaoming Yang , Zhenzhong Wang , Haibo Li , Jianliang Geng

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引用次数: 0

摘要

从益智果中分离并鉴定了两种未描述的倍半萜类化合物，包括一种nor-eusdesmane型（1）和一种guaiane型（2），以及两种已知的类似物（3-4）。通过广泛的光谱分析（1D-、2D-NMR、HRESIMS、IR、UV）和DP4+分析的NMR计算，阐明了这些新化合物的结构。通过测量它们对LPS刺激的RAW 264.7巨噬细胞中PGE2产生的抑制作用来评估所有分离株的抗炎活性。

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Two new sesquiterpenoids from the fruits of Alpinia oxyphylla

Two undescribed sesquiterpenoids, including one nor-eudesmane type (1) and one guaiane type (2), together with two known analogues (3-4) have been isolated and identified from the fruits of Alpinia oxyphylla. The structures of these new compounds were elucidated by extensive spectroscopic analyses (1D-, 2D-NMR, HRESIMS, IR, UV) and NMR calculations with DP4+ analysis. The anti-inflammatory activities of all isolates were evaluated by measuring their inhibitory effects on PGE₂ production in LPS stimulated RAW 264.7 macrophages.

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来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.