结直肠癌癌症诊断生物标志物:超越粪便血红蛋白。

IF 3.2 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
A. Krishnamoorthy, R. Arasaradnam
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引用次数: 0

摘要

结直肠癌癌症(CRC)是全球第三大最常见的癌症,也是全球癌症死亡的第二大原因。癌症的诊断阶段是最重要的预后因素之一,也是改善癌症治疗的潜在目标。早期诊断与更好的预后和治疗后更长的生存时间有关。同时,靶向治疗和免疫疗法的使用正在改善CRC的结果。诊断生物标志物是早期检测和预测治疗反应的关键。目前,血红蛋白的粪便免疫化学检测可能是最广泛的CRC诊断生物标志物。然而,其他生物标志物已被批准用于临床,其他生物标记物则处于临床使用前的研究验证阶段。这篇综述的重点是这些生物标志物背后的证据,它们目前和未来的潜在用途。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Colorectal cancer diagnostic biomarkers: Beyond faecal haemoglobin

Colorectal cancer (CRC) is the third most common cancer worldwide, and the second commonest cause of cancer deaths worldwide. One of the most important prognostic factors, and thus a potential target for improving cancer care, is the stage of cancer at diagnosis. Earlier stage diagnosis is associated with better prognosis and longer survival times after treatment. At the same time, the use of targeted therapies and immunotherapy is improving CRC outcomes. Diagnostic biomarkers are key to both early detection and prediction of treatment responses. Currently faecal immunochemical testing for haemoglobin is perhaps the most widespread CRC diagnostic biomarker. However other biomarkers are approved for clinical use and others are in the validation stage of research prior to clinical use. This review focuses on these the evidence behind these biomarkers, their current and potential future use.

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来源期刊
CiteScore
5.50
自引率
0.00%
发文量
23
审稿时长
69 days
期刊介绍: Each topic-based issue of Best Practice & Research Clinical Gastroenterology will provide a comprehensive review of current clinical practice and thinking within the specialty of gastroenterology.
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