成纤维细胞生长因子2。

IF 2.2 3区生物学 Q4 CELL BIOLOGY

Differentiation Pub Date : 2024-09-01 DOI:10.1016/j.diff.2023.10.001

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引用次数: 0

摘要

成纤维细胞生长因子2（FGF2），也称为碱性成纤维细胞增长因子，是多种组织生长和分化的有力刺激因子。它的发现可以追溯到50多年前，当时它首次从牛垂体提取物中分离出来，因为它能够刺激成纤维细胞增殖。随后对FGF2基因组结构的研究确定了多种蛋白质亚型，分为低分子量和高分子量FGF2。这些异构体来源于可供选择的翻译起始事件，并表现出独特的分子和细胞功能。在这篇简明的综述中，我们的目的是概述目前已知的FGF2亚型在发育、体内平衡和疾病背景下的结构、表达和功能。

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Fibroblast growth factor 2

Fibroblast Growth Factor 2 (FGF2), also known as basic fibroblast growth factor, is a potent stimulator of growth and differentiation in multiple tissues. Its discovery traces back over 50 years ago when it was first isolated from bovine pituitary extracts due to its ability to stimulate fibroblast proliferation. Subsequent studies investigating the genomic structure of FGF2 identified multiple protein isoforms, categorized as the low molecular weight and high molecular weight FGF2. These isoforms arise from alternative translation initiation events and exhibit unique molecular and cellular functions. In this concise review, we aim to provide an overview of what is currently known about the structure, expression, and functions of the FGF2 isoforms within the contexts of development, homeostasis, and disease.

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来源期刊

Differentiation 生物-发育生物学

CiteScore

4.10

自引率

3.40%

发文量

审稿时长

51 days

期刊介绍： Differentiation is a multidisciplinary journal dealing with topics relating to cell differentiation, development, cellular structure and function, and cancer. Differentiation of eukaryotes at the molecular level and the use of transgenic and targeted mutagenesis approaches to problems of differentiation are of particular interest to the journal. The journal will publish full-length articles containing original work in any of these areas. We will also publish reviews and commentaries on topics of current interest. The principal subject areas the journal covers are: • embryonic patterning and organogenesis • human development and congenital malformation • mechanisms of cell lineage commitment • tissue homeostasis and oncogenic transformation • establishment of cellular polarity • stem cell differentiation • cell reprogramming mechanisms • stability of the differentiated state • cell and tissue interactions in vivo and in vitro • signal transduction pathways in development and differentiation • carcinogenesis and cancer • mechanisms involved in cell growth and division especially relating to cancer • differentiation in regeneration and ageing • therapeutic applications of differentiation processes.