母体肥胖和妊娠期糖尿病宫内暴露儿童的瘦素抵抗。

IF 2.7 3区医学 Q1 PEDIATRICS

Pediatric Obesity Pub Date : 2023-10-20 DOI:10.1111/ijpo.13081

Alysha B. Everett, W. Timothy Garvey, Jose R. Fernandez, Kirk Habegger, Lorie M. Harper, Ashley N. Battarbee, Samantha L. Martin, Bethany A. Moore, Amelia E. Fouts, Jessica Bahorski, Paula C. Chandler-Laney

{"title":"母体肥胖和妊娠期糖尿病宫内暴露儿童的瘦素抵抗。","authors":"Alysha B. Everett, W. Timothy Garvey, Jose R. Fernandez, Kirk Habegger, Lorie M. Harper, Ashley N. Battarbee, Samantha L. Martin, Bethany A. Moore, Amelia E. Fouts, Jessica Bahorski, Paula C. Chandler-Laney","doi":"10.1111/ijpo.13081","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Leptin resistance occurs with obesity, but it is unknown if individuals at risk for obesity develop leptin resistance prior to obesity.</p>\n </section>\n \n <section>\n \n <h3> Objective</h3>\n \n <p><b>I</b>nvestigate whether leptin resistance is independent of weight status in children at risk for obesity due to intrauterine exposure to maternal obesity or gestational diabetes mellitus (GDM).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Mother–child dyads (<i>N</i> = 179) were grouped by maternal pregnancy weight and GDM status: (1) normal weight, no GDM; (2) overweight/obesity, no GDM; (3) overweight/obesity with GDM. Children (4–10 years) were further stratified by current body mass index (BMI) <85th or ≥85th percentile. Leptin resistance of children and mothers was calculated as fasting leptin/fat mass index. Two-way ANOVA was used to assess whether leptin concentrations and leptin resistance differed by current weight status or in utero exposure group, after adjusting for race, sex and Tanner stage.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>Children with a BMI ≥85th percentile had more leptin resistance than those with a BMI <85th percentile (<i>p</i> < 0.001), but leptin resistance did not differ by in utero exposure. Similarly, leptin resistance in women was associated with weight status and not prior GDM.</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>Results suggest that leptin concentrations are associated with obesity but not risk for obesity based on in utero exposure to maternal obesity or GDM.</p>\n </section>\n </div>","PeriodicalId":217,"journal":{"name":"Pediatric Obesity","volume":"18 12","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes\",\"authors\":\"Alysha B. Everett, W. Timothy Garvey, Jose R. Fernandez, Kirk Habegger, Lorie M. Harper, Ashley N. Battarbee, Samantha L. Martin, Bethany A. Moore, Amelia E. Fouts, Jessica Bahorski, Paula C. Chandler-Laney\",\"doi\":\"10.1111/ijpo.13081\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Leptin resistance occurs with obesity, but it is unknown if individuals at risk for obesity develop leptin resistance prior to obesity.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Objective</h3>\\n \\n <p><b>I</b>nvestigate whether leptin resistance is independent of weight status in children at risk for obesity due to intrauterine exposure to maternal obesity or gestational diabetes mellitus (GDM).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Mother–child dyads (<i>N</i> = 179) were grouped by maternal pregnancy weight and GDM status: (1) normal weight, no GDM; (2) overweight/obesity, no GDM; (3) overweight/obesity with GDM. Children (4–10 years) were further stratified by current body mass index (BMI) <85th or ≥85th percentile. Leptin resistance of children and mothers was calculated as fasting leptin/fat mass index. Two-way ANOVA was used to assess whether leptin concentrations and leptin resistance differed by current weight status or in utero exposure group, after adjusting for race, sex and Tanner stage.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>Children with a BMI ≥85th percentile had more leptin resistance than those with a BMI <85th percentile (<i>p</i> < 0.001), but leptin resistance did not differ by in utero exposure. Similarly, leptin resistance in women was associated with weight status and not prior GDM.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusions</h3>\\n \\n <p>Results suggest that leptin concentrations are associated with obesity but not risk for obesity based on in utero exposure to maternal obesity or GDM.</p>\\n </section>\\n </div>\",\"PeriodicalId\":217,\"journal\":{\"name\":\"Pediatric Obesity\",\"volume\":\"18 12\",\"pages\":\"\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2023-10-20\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pediatric Obesity\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13081\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"PEDIATRICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pediatric Obesity","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/ijpo.13081","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}

引用次数: 0

摘要

背景：瘦素抵抗与肥胖同时发生，但尚不清楚有肥胖风险的个体是否在肥胖之前产生瘦素抵抗。目的：研究瘦素抵抗是否与因母体肥胖或妊娠期糖尿病（GDM）引起的宫内暴露而有肥胖风险的儿童的体重状况无关 = 179）按孕妇妊娠体重和GDM状况分组：（1）正常体重，无GDM；（2）超重/肥胖，无GDM；（3）患有GDM的超重/肥胖。儿童（4-10 年龄）根据当前体重指数（BMI）进行进一步分层。结果：BMI≥85百分位的儿童比BMI的儿童有更多的瘦素抵抗。结论：结果表明，瘦素浓度与肥胖有关，但与子宫内暴露于母体肥胖或GDM的肥胖风险无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Leptin resistance in children with in utero exposure to maternal obesity and gestational diabetes

Background

Leptin resistance occurs with obesity, but it is unknown if individuals at risk for obesity develop leptin resistance prior to obesity.

Objective

Investigate whether leptin resistance is independent of weight status in children at risk for obesity due to intrauterine exposure to maternal obesity or gestational diabetes mellitus (GDM).

Methods

Mother–child dyads (N = 179) were grouped by maternal pregnancy weight and GDM status: (1) normal weight, no GDM; (2) overweight/obesity, no GDM; (3) overweight/obesity with GDM. Children (4–10 years) were further stratified by current body mass index (BMI) <85th or ≥85th percentile. Leptin resistance of children and mothers was calculated as fasting leptin/fat mass index. Two-way ANOVA was used to assess whether leptin concentrations and leptin resistance differed by current weight status or in utero exposure group, after adjusting for race, sex and Tanner stage.

Results

Children with a BMI ≥85th percentile had more leptin resistance than those with a BMI <85th percentile (p < 0.001), but leptin resistance did not differ by in utero exposure. Similarly, leptin resistance in women was associated with weight status and not prior GDM.

Conclusions

Results suggest that leptin concentrations are associated with obesity but not risk for obesity based on in utero exposure to maternal obesity or GDM.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pediatric Obesity PEDIATRICS-

CiteScore

7.30

自引率

5.30%

发文量

117

审稿时长

6-12 weeks

期刊介绍： Pediatric Obesity is a peer-reviewed, monthly journal devoted to research into obesity during childhood and adolescence. The topic is currently at the centre of intense interest in the scientific community, and is of increasing concern to health policy-makers and the public at large. Pediatric Obesity has established itself as the leading journal for high quality papers in this field, including, but not limited to, the following: Genetic, molecular, biochemical and physiological aspects of obesity – basic, applied and clinical studies relating to mechanisms of the development of obesity throughout the life course and the consequent effects of obesity on health outcomes Metabolic consequences of child and adolescent obesity Epidemiological and population-based studies of child and adolescent overweight and obesity Measurement and diagnostic issues in assessing child and adolescent adiposity, physical activity and nutrition Clinical management of children and adolescents with obesity including studies of treatment and prevention Co-morbidities linked to child and adolescent obesity – mechanisms, assessment, and treatment Life-cycle factors eg familial, intrauterine and developmental aspects of child and adolescent obesity Nutrition security and the "double burden" of obesity and malnutrition Health promotion strategies around the issues of obesity, nutrition and physical activity in children and adolescents Community and public health measures to prevent overweight and obesity in children and adolescents.