脐血低分子量组分（5kDa以下）与Actovegin药物对皮肤冷冻损伤愈合效果的比较评价

Q4 Medicine

Problems of Cryobiology and Cryomedicine Pub Date : 2021-06-30 DOI:10.15407/cryo31.02.116

O. Gulevsky, N. Moisieieva, O. Gorina, Yu. S. Akhatova

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引用次数: 0

摘要

本文介绍了低分子量（低于5kDa）牛脐血组分（CBF）和对照药物Actovegin对大鼠皮肤冷冻消融后组织再生影响的比较研究结果。在这里，局部接触冷冻暴露不仅会破坏所有皮肤层，还会对深层和邻近组织造成继发性缺血性损伤。使用CBF注射溶液作为模拟冷冻损伤的治疗方法证明了其显著的伤口愈合效果，表现为加速修复、改善因过度血管化而受伤区域的营养性以及预防硬化过程。与对照组相比，向大鼠引入CBF和Actovegin在短期内加速了临床血液参数（红细胞和白细胞计数、碱性磷酸酶活性）的正常化。所获得的效果可以与Actovegin的作用进行比较。

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Comparative Evaluation of Wound Healing Effect of Cord Blood Low Molecular Weight Fraction (Below 5 kDa) and Actovegin Drug in Skin Cryolesions

This paper presents the results of comparative studies of the impact of the low molecular weight (below 5 kDa) cattle cord blood fraction (CBF) and the comparator drug Actovegin on tissue regeneration after skin cryoablation in rats. Here, a local contact cryoexposure was shown to result not only in destruction of all skin layers, but secondary ischemic damage to deeper and adjacent tissues as well. The use of an injection solution of CBF as a therapy for simulated cryolesion proved its pronounced wound healing effect, manifested in accelerated reparation, improved trophicity in an injured area due to hypervascularization and prevention of sclerotic processes. The introduction of CBF and Actovegin to rats accelerated the normalization of clinical blood parameters (RBC and WBC counts, alkaline phosphatase activity) in shorter terms as compared with the control. The obtained effect may be compared with Actovegin action.

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来源期刊

Problems of Cryobiology and Cryomedicine Medicine-Medicine (miscellaneous)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The Journal publishes the reviews and original papers on cryobiological and cryomedical research, in particular the elucidation of mechanisms of injuries occurring in biological objects and caused by the influence of low and ultra low temperatures; natural resistance of biologicals to cold and their recovery post effect; the development of effective methods of cryoprotection and technology of storage of biological resources under hypothermic and ultra low temperatures, application of hypothermia, cryotherapy and cryopreserved biologicals for treating various pathologies; cell and tissue based therapies and other issues of low-temperature biology and medicine, as well as development of devices and equipment for low temperature biology and medicine. The journal covers all topics related to low temperature biology, medicine and engineering. These include but are not limited to: low temperature storage of biologicals (human, animal or plant cells, tissues, and organs), including preparation for storage, thawing/warming, cell and tissue culturing etc. response of biologicals to low temperature; cold adaptation of animals and plants; utilisation of low temperature in medicine; experimental and clinical transplantation, cell and tissue based therapies; developing of cryobiological and cryomedical devices; organisation and functioning of low temperature banks etc.