常规跑步机运动改善月经期造血干细胞和姜黄素负载纳米复合水凝胶治疗的大鼠脊髓损伤修复：一项体内外研究

IF 0.9 4区材料科学

Science of Advanced Materials Pub Date : 2023-07-01 DOI:10.1166/sam.2023.4449

Rui Cong, Fenglei Li

{"title":"常规跑步机运动改善月经期造血干细胞和姜黄素负载纳米复合水凝胶治疗的大鼠脊髓损伤修复：一项体内外研究","authors":"Rui Cong, Fenglei Li","doi":"10.1166/sam.2023.4449","DOIUrl":null,"url":null,"abstract":"In the current study, the synergistic healing efficacy of regular treadmill exercise and administration of menstrual blood stem cells and curcumin-loaded calcium alginate hydrogel was investigated. In Vitro studies were used to characterize the hydrogel system In Vitro.\n Various validation methods including BBB assay, histopathological examinations, and gene expression studies were used to assess the healing efficacy of different groups. Study showed that treadmill exercise and the hydrogels loaded with both menstrual blood stem cells and curcumin significantly\n improved the spinal cord injury repair through upregulation of pro-healing genes.","PeriodicalId":21671,"journal":{"name":"Science of Advanced Materials","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2023-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Regular Treadmill Exercise Improves the Spinal Cord Injury Repair in a Rat Model Treated with Menstrual Blood Stem Cells and Curcumin-Loaded Nanocomposite Hydrogel: An In Vitro and In Vivo Study\",\"authors\":\"Rui Cong, Fenglei Li\",\"doi\":\"10.1166/sam.2023.4449\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"In the current study, the synergistic healing efficacy of regular treadmill exercise and administration of menstrual blood stem cells and curcumin-loaded calcium alginate hydrogel was investigated. In Vitro studies were used to characterize the hydrogel system In Vitro.\\n Various validation methods including BBB assay, histopathological examinations, and gene expression studies were used to assess the healing efficacy of different groups. Study showed that treadmill exercise and the hydrogels loaded with both menstrual blood stem cells and curcumin significantly\\n improved the spinal cord injury repair through upregulation of pro-healing genes.\",\"PeriodicalId\":21671,\"journal\":{\"name\":\"Science of Advanced Materials\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2023-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science of Advanced Materials\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://doi.org/10.1166/sam.2023.4449\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science of Advanced Materials","FirstCategoryId":"88","ListUrlMain":"https://doi.org/10.1166/sam.2023.4449","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

摘要

在目前的研究中，研究了定期跑步机运动和经血干细胞和姜黄素负载的海藻酸钙水凝胶的协同愈合效果。使用体外研究来表征水凝胶系统的体外特性。使用包括血脑屏障测定、组织病理学检查和基因表达研究在内的各种验证方法来评估不同组的愈合效果。研究表明，平板运动和负载经血干细胞和姜黄素的水凝胶通过上调促愈合基因显著改善了脊髓损伤的修复。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Regular Treadmill Exercise Improves the Spinal Cord Injury Repair in a Rat Model Treated with Menstrual Blood Stem Cells and Curcumin-Loaded Nanocomposite Hydrogel: An In Vitro and In Vivo Study

In the current study, the synergistic healing efficacy of regular treadmill exercise and administration of menstrual blood stem cells and curcumin-loaded calcium alginate hydrogel was investigated. In Vitro studies were used to characterize the hydrogel system In Vitro. Various validation methods including BBB assay, histopathological examinations, and gene expression studies were used to assess the healing efficacy of different groups. Study showed that treadmill exercise and the hydrogels loaded with both menstrual blood stem cells and curcumin significantly improved the spinal cord injury repair through upregulation of pro-healing genes.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Science of Advanced Materials NANOSCIENCE & NANOTECHNOLOGY-MATERIALS SCIENCE, MULTIDISCIPLINARY

自引率

11.10%

发文量

审稿时长

4.4 months