CIITA基因在黏膜相关淋巴组织淋巴瘤中的研究进展

国际输血及血液学杂志 Pub Date : 2019-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2019.06.012

Y. Wan, Tao Wu

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引用次数: 0

摘要

主要组织相容性复合体Ⅱ类分子横向激活因子（CⅡTA）是一种转录激活因子，被认为是主要组织相容复合体（MHC）Ⅱ类表达的主要调控因子。CⅡTA基因通过影响MHCⅡ类分子的转录水平来调节免疫功能。粘膜相关淋巴组织（MALT）淋巴瘤是一种起源于淋巴结外缘MALT的B细胞淋巴瘤。肿瘤细胞表面缺乏MHCⅡ类分子表达，导致肿瘤细胞逃避免疫监测。这是MALT淋巴瘤的重要发病机制。本文就CⅡTA基因在MALT淋巴瘤中表达的意义及研究进展作一综述。关键词：淋巴瘤，B细胞，边缘区；基因，MHCⅡ类；激活转录因子；免疫调节；分子靶向治疗；CⅡTA基因

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Research progress of CIITA gene in mucosa-associated lymphoid tissue lymphoma

Main tissue compatibility complex class Ⅱ molecular transverse activation factor (CⅡTA) is a transcribed activation factor which is considered the main regulatory factors in the major histocompatibility complex (MHC) class Ⅱ expression. CⅡTA gene regulates the immune function by affecting the transcription level of MHC class Ⅱ molecules. Mucosa-associated lymphoid tissue (MALT) lymphoma is a type of B-cell lymphoma originated from MALT at the outer margin of lymph nodes. The absence of MHC class Ⅱ molecular expression on the surface of tumor cells, causes tumor cells to evade immune surveillance. This is an important pathogenesis of MALT lymphoma. Here, the article reviews the significance and research progress of the expression of CⅡTA gene in MALT lymphoma. Key words: Lymphoma, B-cell, marginal zone; Genes, MHC class Ⅱ; Activating transcription factors; Immunomodulation; Molecular targeted therapy; CⅡTA gene

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来源期刊

国际输血及血液学杂志

自引率

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发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.