高sn-2棕榈酸婴儿配方奶粉对婴儿脂肪酸、钙和镁排泄的影响

Q4 Nursing

中华临床营养杂志 Pub Date : 2018-08-30 DOI:10.3760/CMA.J.ISSN.1674-635X.2018.04.004

Jialu Zhuang, F. Bei, Yishi Qin, Jianhua Sun

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引用次数: 1

摘要

目的探讨高sn-2棕榈酸婴儿配方奶粉（HPIF）对婴儿排便次数、大便稠度、脂肪酸、钙、镁含量的影响。方法采用前瞻性、双盲、随机、对照的临床研究方法，对2013年6月至2014年12月出生的94名符合孕龄的单胎健康成年婴儿进行研究。所有符合条件的婴儿在出生后21天内登记。所有婴儿配方奶粉喂养的受试者被随机分为两组，即标准婴儿配方奶粉（IF）组和高sn-2棕榈酸婴儿配方奶粉组。母乳喂养婴儿作为对照组（BF组）。所有婴儿随访至90天。动态监测三组大鼠生长指标及排便情况。同时，还检测了粪便脂肪酸和矿物质含量。结果入组时、42日龄和90日龄三组的头围、身长和体重无显著差异。HPIF组和IF组在42日龄和90日龄时大便次数和糊状大便次数均显著低于BF组；HPIF和IF组形成大便的频率高于BF组。42日龄时，HPIF和IF组干粪中的粪便棕榈酸水平显著高于BF组[（31.1±9.8），（30.9±10.7）vs.（10.8±8.8）mg/g]。90日龄时，HPIF组干粪中的粪便棕榈酸水平显著低于IF组[（24.3±9.8）vs.（29.9±7.9）mg/mg]，在42日龄时，HPIF和IF组干粪中的钙水平显著高于BF组[（38.3±14.0），（38.8±15.5）vs.（21.3±13.7）mg/g]。90日龄时，HPIF组干粪中的粪钙水平显著低于IF组[（31.1±11.2）vs.（45.9±16.5）mg/g]，显著高于BF组[（21.5±9.9）mg/g]。三组婴儿粪便钙水平与粪便棕榈酸含量呈正相关（r=0.43，P<0.01）。与标准婴儿配方奶粉相比，喂食高sn-2棕榈酸婴儿配方奶粉可以减少钙和棕榈酸的粪便排泄，使其更接近母乳喂养婴儿的水平。关键词：婴儿配方奶粉；脂肪酸；棕榈酸；钙；高sn-2棕榈酸酯

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Effect of high sn-2 palmitate infant formula on the excretion of fatty acids, calcium and magnesium in infants

Objective To explore the effect of high sn-2 palmitate infant formula (HPIF) on stool frequency and consistency, fatty acids, calcium and magnesium contents in infants. Methods A prospective, double-blind, randomized, controlled clinical study was conducted including 94 healthy mature infants of single birth and appropriate for gestational age, born from June 2013 to December 2014. All eligible infants were enrolled within 21 days after birth. All the infant formula fed subjects were divided randomly into two groups as standard infant formula (IF) group and high sn-2 palmitate infant formula (HPIF) group. Breast-fed infants were enrolled as control group (BF group). All infants were followed up until 90 days old. The growth indexes and defecation status of the three groups were monitored dynamically. Meanwhile, stool fatty acid profile and mineral contents were also detected. Results There was no significant difference in head circumference, body length and body weight among the three groups at enrollment, 42 days and 90 days old. The stool frequency and mushy stool frequency of HPIF and IF groups were significantly lower than that of BF group at 42 days and 90 days old; formed stool frequency was higher in HPIF and IF groups than in BF group. The fecal palmitic acid level in dry feces was significantly higher in HPIF and IF groups than in BF group [(31.1±9.8), (30.9±10.7) vs. (10.8±8.8)mg/g] at 42 days old. At 90 days old, the fecal palmitic acid level in dry feces was significantly lower in HPIF group than in IF group [(24.3±9.8) vs. (29.9±7.9)mg/mg], while was significantly higher in both infant formula fed groups than in BF group [(8.9±8.4)mg/g]. The fecal calcium level in dry feces of HPIF and IF groups were significantly higher than that of BF group [(38.3±14.0), (38.8±15.5) vs. (21.3±13.7)mg/g] at 42 days old. At 90 days old, the fecal calcium level in dry feces of HPIF group was significantly lower than that of IF group [(31.1 ± 11.2) vs. (45.9 ± 16.5)mg/g, dry stool] and significantly higher than that of BF group [(21.5 ± 9.9)mg/g]. The fecal magnesium level was similar between HPIF and IF groups, and significantly higher than that of BF group at 42 days and 90 days old. The fecal calcium level was positively correlated with the content of fecal palmitic acid among three groups (r=0.43, P<0.01). Conclusions Breast milk is the best food for infants. Compared with standard infant formula, feeding with high sn-2 palmitate infant formula can reduce the fecal excretion of calcium and palmitic acid, making it closer to the level of breast-fed infants. Key words: Infant formula; Fatty acids; Palmitic acid; Calcium; High sn-2 palmitate

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来源期刊

中华临床营养杂志 Nursing-Nutrition and Dietetics

CiteScore

0.20

自引率

0.00%

发文量

2282

期刊介绍： The Chinese Journal of Clinical Nutrition was founded in 1993. It is the first professional academic journal (bimonthly) in my country co-sponsored by the Chinese Medical Association and the Chinese Academy of Medical Sciences to disseminate information on clinical nutrition support, nutrient metabolism, the impact of nutrition support on outcomes and "cost-effectiveness", as well as translational medicine and nutrition research. It is also a professional journal of the Chinese Medical Association's Parenteral and Enteral Nutrition Branch. The purpose of the Chinese Journal of Clinical Nutrition is to promote the rapid dissemination of knowledge on nutrient metabolism and the rational application of parenteral and enteral nutrition, focusing on the combination of multidisciplinary and multi-regional field investigations and clinical research. It mainly reports on nutritional risk screening related to the indications of parenteral and enteral nutrition support, "cost-effectiveness" research on nutritional drugs, consensus on clinical nutrition, guidelines, expert reviews, randomized controlled studies, cohort studies, glycoprotein and other nutrient metabolism research, systematic evaluation of clinical research, evidence-based case reports, special reviews, case reports and clinical experience exchanges, etc., and has a special column on new technologies related to the field of clinical nutrition and their clinical applications.