暴露于BPA及其替代品，如BPB、BPF和BPS，会损害成年雌性Sprague-Dawley大鼠随后的生殖潜力

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2020-01-02 DOI:10.1080/15376516.2019.1652873

Saman Ijaz, Asad Ullah, G. Shaheen, S. Jahan

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引用次数: 36

摘要

摘要双酚A及其替代品广泛应用于家庭和工业产品中。BPA及其替代品对雌激素受体具有亲和力，并模仿其作用。本研究旨在检验BPA及其替代品双酚B（BPB）、双酚F（BPF）和双酚S（BPS）对成年雌性大鼠生殖健康的比较影响。170只断奶后雌性大鼠（90只 ± 25）被分为17组，并被分配用于不同的治疗。对照组和治疗组注射浓度为50–500 µg/ml和5-50 mg/kg BPA、BPB、BPF和BPS 28 天。结果显示，所有治疗组大鼠卵巢的形态学和组织病理学均有不良改变。BPA及其替代品5和50的窦卵泡和黄体卵泡显著减少，而闭锁卵泡和囊性卵泡增加 mg/kg处理组与对照组相比。当BPA及其替代品组与对照组相比时，过氧化氢酶（CAT）、超氧化酶（SOD）和过氧化物酶（POD）水平显著降低，而硫代巴比妥酸反应物质（T-BARS）和活性氧（ROS）的值增加。当将治疗组与对照组进行比较时，还观察到激素的浓度发生了变化。目前的数据表明，青春期前暴露于BPA及其替代品有可能在雌性大鼠卵泡发育过程中诱导氧化应激和组织病理学变化。

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Exposure of BPA and its alternatives like BPB, BPF, and BPS impair subsequent reproductive potentials in adult female Sprague Dawley rats

Abstract Bisphenol A (BPA) and its alternatives are extensively used in household and industrial products. BPA and its alternatives have affinity for estrogen receptors and mimic its actions. The present study aims to examine the comparative effects of BPA and its alternatives bisphenol B (BPB), bisphenol F (BPF), and bisphenol S (BPS) on the reproductive health in adult female rats. One hundred and seventy post-weaning female rats (90 ± 25) were divided into 17 groups and assigned for different treatments. Control and treated groups were injected with concentrations of 50–500 µg/ml and 5–50 mg/kg of BPA, BPB, BPF, and BPS for 28 days. The results showed adverse morphological and histopathological alterations in rat ovaries in all treated groups. A remarkable decrease was observed in antral and corpus luteum follicles while rise in atretic and cystic follicles in the ovaries of BPA and its alternatives 5 and 50 mg/kg treated groups when compared with control. Significant decrease in catalase (CAT), super oxidase (SOD), and peroxidase (POD) levels was noted while increase in the values of thiobarbituric acid reactive substance (T-BARS) and reactive oxygen species (ROS) was observed when BPA and its alternatives groups were compared with the control. Hormones were also observed with alterations in their concentrations when treated groups were compared with the control. The current data suggest that BPA and its alternatives exposure during the pre-pubertal stage have the potential to induce oxidative stress and histopathological changes during follicular development in female rats.

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.