与蠕虫合作:秀丽隐杆线虫作为模式生物

Philip M. Meneely, Caroline L. Dahlberg, Jacqueline K. Rose
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引用次数: 48

摘要

自50年前作为实验室生物引入以来,线虫秀丽隐杆线虫已成为生物学和基因组研究几乎所有方面使用最广泛、用途最广泛的模型之一。秀丽隐杆线虫的许多实验都是从产生和分析影响特定生物过程的突变体开始的,因此遗传技术是蠕虫研究的基础。秀丽隐杆线虫研究生物学的许多不同方面,最近三次不同的诺贝尔奖表彰了六名研究蠕虫的研究人员。此外,秀丽隐杆线虫是第一个对其基因组进行测序的多细胞生物,因此许多标准的基因组方法也在秀丽隐杆虫中被首创。事实上,许多新技术和想法最初都是在秀丽隐杆线虫身上测试的,因为它作为一种研究生物具有多功能性。它也适用于向本科生介绍研究,并讨论了它在这方面的一些优势和挑战。©2019作者。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Working with Worms: Caenorhabditis elegans as a Model Organism

Working with Worms: Caenorhabditis elegans as a Model Organism

Since its introduction as a laboratory organism 50 years ago, the nematode worm Caenorhabditis elegans has become one of the most widely used and versatile models for nearly all aspects of biological and genomic research. Many experiments in C. elegans begin with the generation and analysis of mutants that affect a specific biological process, so genetic techniques are the foundation of worm research. Many different aspects of biology are being studied in C. elegans, and three different recent Nobel Prizes have recognized six researchers working with worms. In addition, C. elegans was the first multicellular organism to have its genome sequenced, so many of the standard genomic methods have also been pioneered in C. elegans. In fact, many novel techniques and ideas are initially tested in C. elegans because of its versatility as a research organism. It is also appropriate for introducing undergraduate students to research, and some of its strengths and challenges for this purpose are discussed. © 2019 The Authors.

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