冠状病毒相关眼部表现的更新:从过去到新冠肺炎大流行

IF 0.5 Q4 PEDIATRICS
Hossein Teimouri, S. A. Rasoulinejad
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引用次数: 1

摘要

背景:冠状病毒是与某些眼部表现相关的最大的RNA病毒。关于冠状病毒在人类的眼部表现,有各种相互矛盾的报道。不同的眼组织会影响冠状病毒相关的传染病。证据收集:所有手稿均来自PubMed、Google Scholar和其他相关数据库。所有搜索都是按特定关键词进行的,包括“冠状病毒”、“眼病”和“眼睛”。结果:关于冠状病毒对人类眼睛的影响,有各种相互矛盾的报道。不同的眼组织与冠状病毒相关的传染病有关。上呼吸道和眼粘膜之间通过鼻泪管的导管连接可能是呼吸道病毒(如冠状病毒)的入口。冠状病毒可以感染眼睛的视网膜、结膜、角膜和葡萄膜。主要的严重急性呼吸系统综合征冠状病毒2型受体ACE2主要在眼睛的后部组织中表达,如视网膜和视网膜色素上皮。猫冠状病毒、严重急性呼吸系统综合征冠状病毒、MERS-CoV和传染性支气管炎病毒(IBV)是结膜参与冠状病毒相关眼部发病机制的原因。此外,还对新冠肺炎以及结膜对诊断和并发症的影响进行了各种研究。鉴于与肺组织相比,角膜具有可接受的ACE2和TMPRSS2基因表达,因此对角膜在新冠肺炎中的影响进行了一些研究。猫传染性腹膜炎病毒(FIPV)也与葡萄膜并发症有关。在各种冠状病毒流行以及新的和未知的眼部并发症的情况下,人类和动物模型对冠状病毒对视网膜和角膜影响的实验可能对未来的研究有很大帮助。结论:鉴于研究严重急性呼吸系统综合征冠状病毒2型感染的发病机制和其他途径的重要性,特别是在呼吸道以外的地区,本报告试图强调该病毒引起的眼部感染的重要性、其在维持病毒传播链中的作用及其对公众健康的影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Updates on Coronavirus-Related Ocular Manifestations: From the Past to COVID-19 Pandemic
Context: Coronaviruses are the largest RNA viruses associated with some ocular manifestations. There are various contradictory reports about the ocular manifestations of coronaviruses in humans. Different ocular tissues can affect coronavirus-associated infectious diseases. Evidence Acquisition: All manuscripts were collected from PubMed, Google Scholar, and other relevant databases. All searches were done by specific keywords, including "coronavirus," "ocular disease," and "eye." Results: There are various contradictory reports about the ocular effects of coronaviruses in humans. Different ocular tissues are involved in coronavirus-associated infectious diseases. The ductal connection between the upper respiratory tract and eye mucosa through the nasolacrimal duct can be an entrance to respiratory viruses, such as coronaviruses. The coronavirus can infect the retina, conjunctiva, cornea, and uvea of the eye. The primary SARS-CoV-2 receptor, ACE2, is mainly expressed in the posterior tissues of the eye, such as the retina and RPE. Feline CoV, SARS-CoV, MERS-CoV, and infectious bronchitis virus (IBV) are responsible for conjunctiva involvement in coronavirus-related ocular pathogenesis. Also, various studies are held on COVID-19 and the impact of the conjunctiva on diagnosis and medical complications. Given that the cornea has an acceptable expression of ACE2 and TMPRSS2 genes compared to lung tissue, some studies were done on the impact of the cornea in COVID-19. Feline infectious peritonitis virus (FIPV) is also related to uvea complications. The experiments of human and animal models on the effects of coronaviruses on the retina and cornea in the event of various epidemics of coronaviruses and new and unknown ocular complications can be of great help to future studies. Conclusions: Given the importance of investigating the pathogenesis and other routes of SARS-CoV-2 infection, especially in areas other than the respiratory tract, this report attempts to highlight the importance of eye infections caused by the virus, its role in maintaining the virus transmission chain, and its impact on public health.
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来源期刊
CiteScore
1.80
自引率
14.30%
发文量
22
期刊介绍: Archives Of Pediatric Infectious Disease is a clinical journal which is informative to all practitioners like pediatric infectious disease specialists and internists. This authoritative clinical journal was founded by Professor Abdollah Karimi in 2012. The Journal context is devoted to the particular compilation of the latest worldwide and interdisciplinary approach and findings including original manuscripts, meta-analyses and reviews, health economic papers, debates and consensus statements of clinical relevance to pediatric disease field, especially infectious diseases. In addition, consensus evidential reports not only highlight the new observations, original research and results accompanied by innovative treatments and all the other relevant topics but also include highlighting disease mechanisms or important clinical observations and letters on articles published in the journal.
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