Greenhydropropes辅助路线——一种提取植物成分和相关药物递送系统的替代方法

Q2 Pharmacology, Toxicology and Pharmaceutics
Devika Tripathi, Nandini Chaudhary, P. Wal, A. Rai, Jagannath Sahoo
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引用次数: 0

摘要

研究人员面临的极具挑战性的任务是从天然存在的草药中分离和提取主要药用植物成分。复杂的提取过程通常包括植物和活性动物部分,通过标准程序进行药物分离和选择性溶剂。因此,大多数产品都含有复杂的代谢产物混合物;因此,分离这些产物所涉及的提取过程周期使其变得越来越困难,并以小数表示产率。因此,最近从可持续资源中获得了一种适用于绿色提取路线的替代策略,该资源具有高偿付能力、低毒性和低环境影响、易于生物降解和回收而不会对环境产生有害影响。绿色水力绳索辅助提取工艺是一种新颖而有前景的方法。与传统提取工艺相比,它通过使用各种水溶性溶剂,如枯烯磺酸钠、烷基苯磺酸钠和丁基单甘醇硫酸钠,最大限度地提高了植物成分的产量。它还参与通过细胞透化破坏磷脂双层和上述亲水分子来选择性提取水不溶性植物成分,破坏纤维素细胞壁,然后可能溶解细胞内容物。本次审计的中心点是通过考虑绿色亲水性辅助提取工艺,分配用于提取草药植物的可溶性物质,批准亲水性物质及其成分,迫切需要强调从草药植物中分离出来的植物成分的转运框架,以提高其在不同目标目的地的生物利用度,并有效地反映了其不同的效用角度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Greenhydrotropes-assisted route an alternative approach for extracting phytoconstituents and associateddrug delivery systems
Critically challenging tasks for the researchers are isolation and extraction of chief medicinally phytoconstituents from naturally existing herbal plants. The intricate process of extraction usually involves both plant and active animal portions medicinally separated and selective solvents through standard procedures. So, most of the products contain complex mixtures of metabolites; therefore, the extraction process cycle involved in separating these products makes it increasingly difficult and indicated yields in decimals. Thus, an alternative strategy suitable for green extraction routes has recently been obtained from sustainable resources with high solvency, low toxicity, and low environmental impacts, readily biodegradable, and recycled without detrimental effects on the environment. The process of the green hydrotrope-assisted extraction process persists in a novel and promising methodology. It maximizes the yield of phytoconstituents compared to the conventional extraction process by the employment of a variety of hydrotropes like sodium cumene sulfonate, sodium alkyl-benzene sulfonates, and sodium butyl mono-glycol sulfate. It is also involved in selective extraction of water-insoluble phytoconstituents by disorganization of the phospholipid bilayers and the aforementioned hydrotrope molecules through cell permeabilization, disrupting the cellulosic cell wall, then possibly the dissolution of the cellular contents. The central point of this audit is the increase of the surrender of phytoconstituents from herbal plants accomplished by the consideration of green hydrotropic-assisted extraction process, an assignment of dissolvable for the extraction of herbal grown plant, sanctioning of hydrotropes, its component, imperatively highlighting conveyance frameworks of separated extricated phytoconstituents from herbal plants to move forward their bioavailability at distinctive target destinations and its different utility angles have reflected effectively.
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来源期刊
Drug Delivery Letters
Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
CiteScore
1.70
自引率
0.00%
发文量
30
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