A comparative study on the efficacy of oral midazolam and oral triclofos sodium for conscious sedation in pediatric group of patients

Background: Behavioral management and carrying out surgical procedures for very young, uncooperative, anxious children can be challenging. It is usually encountered in children below the age of 6 years due to the following contributing factors such as immature reasoning, anxiety, fear, and inadequate coping skills. The goal of the study was to compare the efficacy of oral midazolam and oral triclofos sodium for conscious sedation in pediatric group of patients before elective surgeries. Materials and Methods: This prospective, single- blinded, randomized controlled, comparative study was conducted in 60 patients aged 2–8 years who were scheduled for elective surgery. The patients were randomly divided into two groups: M and T of 30 children each, where group M received 0.5 mg//kg midazolam and group T received 75 mg/kg triclofos sodium, orally, 60 min prior to anesthetic induction. The hemodynamics, acceptability of drugs, depth of sedation, and anxiety during separation from parents were assessed. Fisher’s exact test, chi-square test, and Student’s t test were applied to find significance. Results: The mean systolic and diastolic blood pressure, heart rate, respiration rate, and oxygen saturation at baseline to 60 min in groups M and T showed no significant difference between groups. Triclofos sodium has better acceptability over oral midazolam, whereas oral midazolam has better sedative properties over oral triclofos sodium. Conclusion: Oral midazolam was found to be more effective premedication and may be preferred over triclofos sodium due to the rapid and better sedative effect as well as good anxiolysis properties.