新冠肺炎大流行的临床记忆：急性冠状动脉综合征患者临床和血管造影特征的比较分析

IF 0.2 Q4 CARDIAC & CARDIOVASCULAR SYSTEMS

Pakistan Heart Journal Pub Date : 2023-04-01 DOI:10.47144/phj.v56i1.2450

Atif Sher Muhammad, A. Ammar, Bella Khan, Danish Qayyum, U. H. Bhatti, Maroof Hassan, Arti Ashok, T. Saghir, F. Ali, N. Salahuddin

{"title":"新冠肺炎大流行的临床记忆：急性冠状动脉综合征患者临床和血管造影特征的比较分析","authors":"Atif Sher Muhammad, A. Ammar, Bella Khan, Danish Qayyum, U. H. Bhatti, Maroof Hassan, Arti Ashok, T. Saghir, F. Ali, N. Salahuddin","doi":"10.47144/phj.v56i1.2450","DOIUrl":null,"url":null,"abstract":"Objectives: To describe the clinical characteristics and angiographic features of COVID-19 patients presenting with acute coronary syndrome (ACS) and to compare with non-COVID-19 ACS patients presenting simultaneously.\nMethodology: In a case control design, data were extracted from a prospectively collected COVID-19 and NCDR registry. All ACS patients who underwent cardiac catheterization from April 2020 to May 2021 were included. All of the patients were taken to the Cath lab for diagnostic coronary angiography and possible percutaneous intervention. Demographic and clinical characteristics, angiographic features, and in-hospital outcomes were compared between ACS patients with and without COVID-19.\nResults: A total of 4027 COVID-19 negative patients, and 80 COVID-19 positive were included. Total of 83% in COVID-19 and 88% in non-COVID-19 group had ST elevation myocardial infarction. Majority of the COVID-19 positive patients had sub-optimal TIMI flow grade (<III) post procedure and had a high thrombus burden (11.2% vs. 2.9%; p<0.001). Majority of the patients who had COVID-19 and ACS required mechanical circulatory support (48.8% vs. 0.3%; p<0.001). The mortality rates were also higher in COVID-19 positive group (38.8% vs. 1.3%; p<0.001). Among the COVID-19 positive patients 66.3% (53) had high thrombus burden (≥4 grade), intervention was performed in 73.7% (59). Post-intervention myocardial blush grade ≤2 was observed in 57.6% (34), slow flow in 85.3% (29), and phasic flow possibly due to elevated LVEDP in 41.2% (14) patients.\nConclusion: COVID-19 patients with ACS had a higher severity of illness at presentation and worse outcomes as compared to simultaneously presenting non-COVID patients.","PeriodicalId":42273,"journal":{"name":"Pakistan Heart Journal","volume":" ","pages":""},"PeriodicalIF":0.2000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Clinical Memory of COVID-19 Pandemic: A Comparative Analysis of Clinical and Angiographic Characteristics of Patients with Acute Coronary Syndrome\",\"authors\":\"Atif Sher Muhammad, A. Ammar, Bella Khan, Danish Qayyum, U. H. Bhatti, Maroof Hassan, Arti Ashok, T. Saghir, F. Ali, N. Salahuddin\",\"doi\":\"10.47144/phj.v56i1.2450\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objectives: To describe the clinical characteristics and angiographic features of COVID-19 patients presenting with acute coronary syndrome (ACS) and to compare with non-COVID-19 ACS patients presenting simultaneously.\\nMethodology: In a case control design, data were extracted from a prospectively collected COVID-19 and NCDR registry. All ACS patients who underwent cardiac catheterization from April 2020 to May 2021 were included. All of the patients were taken to the Cath lab for diagnostic coronary angiography and possible percutaneous intervention. Demographic and clinical characteristics, angiographic features, and in-hospital outcomes were compared between ACS patients with and without COVID-19.\\nResults: A total of 4027 COVID-19 negative patients, and 80 COVID-19 positive were included. Total of 83% in COVID-19 and 88% in non-COVID-19 group had ST elevation myocardial infarction. Majority of the COVID-19 positive patients had sub-optimal TIMI flow grade (<III) post procedure and had a high thrombus burden (11.2% vs. 2.9%; p<0.001). Majority of the patients who had COVID-19 and ACS required mechanical circulatory support (48.8% vs. 0.3%; p<0.001). The mortality rates were also higher in COVID-19 positive group (38.8% vs. 1.3%; p<0.001). Among the COVID-19 positive patients 66.3% (53) had high thrombus burden (≥4 grade), intervention was performed in 73.7% (59). Post-intervention myocardial blush grade ≤2 was observed in 57.6% (34), slow flow in 85.3% (29), and phasic flow possibly due to elevated LVEDP in 41.2% (14) patients.\\nConclusion: COVID-19 patients with ACS had a higher severity of illness at presentation and worse outcomes as compared to simultaneously presenting non-COVID patients.\",\"PeriodicalId\":42273,\"journal\":{\"name\":\"Pakistan Heart Journal\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.2000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pakistan Heart Journal\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.47144/phj.v56i1.2450\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pakistan Heart Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.47144/phj.v56i1.2450","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}

引用次数: 0

摘要

目的：描述新冠肺炎急性冠状动脉综合征（ACS）患者的临床特征和血管造影特征，并与同时出现ACS的非新冠肺炎ACS患者进行比较。方法：在病例对照设计中，从前瞻性收集的新冠肺炎和NCDR登记中提取数据。纳入2020年4月至2021年5月期间接受心导管插入术的所有ACS患者。所有患者都被送往Cath实验室进行诊断性冠状动脉造影和可能的经皮介入治疗。比较了有新冠肺炎和无新冠肺炎的ACS患者的人口学和临床特征、血管造影特征和住院结果。结果：共包括4027名新冠肺炎阴性患者和80名新冠肺炎阳性患者。新冠肺炎组和非新冠肺炎组分别有83%和88%的患者发生ST段抬高心肌梗死。大多数新冠肺炎阳性患者术后TIMI血流分级（＜III）次优，血栓负担高（11.2%对2.9%；p＜0.001）。大多数患有新冠肺炎和ACS的患者需要机械循环支持（48.8%对0.3%；p＜0.01）。新冠肺炎阳性组的死亡率也较高（38.8%对1.3%；p＜001）66.3%（53）有高血栓负荷（≥4级），73.7%（59）进行了干预。在57.6%（34）的患者中观察到干预后心肌红分级≤2，85.3%（29）的患者观察到缓慢血流，41.2%（14）的患者可能由于LVEDP升高而出现阶段性血流。结论：与同时出现ACS的非COVID患者相比，患有ACS的新冠肺炎患者在出现时疾病严重程度更高，结果更差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Clinical Memory of COVID-19 Pandemic: A Comparative Analysis of Clinical and Angiographic Characteristics of Patients with Acute Coronary Syndrome

Objectives: To describe the clinical characteristics and angiographic features of COVID-19 patients presenting with acute coronary syndrome (ACS) and to compare with non-COVID-19 ACS patients presenting simultaneously. Methodology: In a case control design, data were extracted from a prospectively collected COVID-19 and NCDR registry. All ACS patients who underwent cardiac catheterization from April 2020 to May 2021 were included. All of the patients were taken to the Cath lab for diagnostic coronary angiography and possible percutaneous intervention. Demographic and clinical characteristics, angiographic features, and in-hospital outcomes were compared between ACS patients with and without COVID-19. Results: A total of 4027 COVID-19 negative patients, and 80 COVID-19 positive were included. Total of 83% in COVID-19 and 88% in non-COVID-19 group had ST elevation myocardial infarction. Majority of the COVID-19 positive patients had sub-optimal TIMI flow grade (

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊