感觉死亡，活着：4-甲基乙卡西酮/戊酮成瘾和3-甲氧基苯环利定中毒

IF 1.1 Q3 Medicine

Addictive Disorders & Their Treatment Pub Date : 2020-07-07 DOI:10.1097/ADT.0000000000000214

L. R. V. D. Bersselaar, J. G. V. D. Hoeven, B. D. Jong

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引用次数: 0

摘要

新型精神活性物质（NPS），也称为设计药物或法定兴奋剂，代表了一系列不同的药理学活性物质。它们被作为可卡因、海洛因、大麻和亚甲二氧基甲基苯丙胺等既定药物的替代品出售。在欧洲青少年中，NPS越来越受欢迎。尽管NPS的使用越来越多，但有关其急性健康影响的信息仍然很少，而且对于NPS的长期影响或成瘾潜力来说更为严重。报告了严重或致命的NPS中毒病例。尽管几位作者对合成卡西酮的成瘾潜力提出了警告，但很少有病例报告或更大规模的人类研究。我们报告了一例对4-甲基乙卡西酮/戊烯酮上瘾的患者和一例对3-甲氧基苯环啶-哌啶-环己烷腈急性中毒的患者。这一案例表明，合成卡西酮的成瘾潜力不容低估。

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Feeling Death, Being Alive: 4-Methylethcathinone/Pentedrone Addiction and 3-Methoxyphencyclidine Intoxication

New psychoactive substances (NPS), also known as designer drugs or legal highs, represent a broad range of different pharmacologically active substances. They are sold as replacements to established drugs such as cocaine, heroin, cannabis, and methylenedioxymethamphetamine. Among adolescents in Europe, NPS are gaining popularity. Despite the increasing use of NPS, information about the acute health effects remains scarce and is evenworse for the long-term effects or the addictive potential of NPS. Severe or fatal cases of NPS intoxications are reported. Although several authors warn about the addictive potential of synthetic cathinones, case reports or larger studies in humans are scarce. We present the case of a patient addicted to 4-methylethcathinone/pentedrone and an acute intoxication with 3-methoxyphencyclidine-piperidine cyclohexane carbonitrile. This case shows that the addictive potential of synthetic cathinones should not be underestimated.

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来源期刊

Addictive Disorders & Their Treatment SUBSTANCE ABUSE-

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期刊介绍： Addictive Disorders & Their Treatment is a quarterly international journal devoted to practical clinical research and treatment issues related to the misuses of alcohol and licit and illicit drugs and the study and treatment of addictive disorders and their behaviors. The journal publishes broad-spectrum, patient-oriented coverage of all aspects of addiction, directed toward an audience of psychiatrists, clinical psychologists, psychopharmacologists, and primary care practitioners. Original articles help clinicians make more educated, effective decisions regarding optimal patient management and care. In-depth reviews examine current understanding, diagnosis, and treatment of addiction disorders.