肾康注射液对单侧输尿管梗阻小鼠肾血管生成的影响

IF 0.9 4区医学 Q4 PHARMACOLOGY & PHARMACY

Bangladesh Journal of Pharmacology Pub Date : 2020-03-09 DOI:10.3329/bjp.v15i1.42052

Yajing Pan, Lu Zhang, Tonghua Liu, Lili Wu

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引用次数: 0

摘要

本研究旨在探讨肾康注射液对肾纤维化小鼠血管生成的影响。C57BL/6J小鼠单侧输尿管梗阻后，给予不同剂量的肾康注射液治疗2周。氯沙坦给药小鼠和Sham手术小鼠分别作为阳性和阴性对照。观察肾功能和血管系统的变化，并检测VEGF和VEGFR2的表达。肾康注射液降低了血清尿素氮、肌酐和胱抑素C的水平。肾康注射液减轻了梗阻肾脏中微血管的损失，减少了胶原纤维的沉积，并增加了VEGF和VEGFR2的表达。这些发现表明，肾康注射液通过调节肾血管生成来减轻肾纤维化小鼠的肾功能障碍和纤维化变化。方法学视频剪辑：肾血管造影：6分41秒：全屏交替

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Effects of shenkang injection on renal angiogenesis in mice with unilateral ureteral obstruction

This study aimed to investigate effects of shenkang injection on angiogenesis in mice with renal fibrosis. C57BL/6J mice after unilateral ureteral obstruction were administrated with different doses of shenkang injection for two weeks. Losartan-administrated mice and Sham-operation mice were as positive and negative controls, respectively. Renal function and vasculature changes were observed, and expressions of VEGF and VEGFR2 were detected. Shenkang injection reduced serum levels of urea nitrogen, creatinine and cystatin C. Shenkang injection alleviated the loss of microvessels, decreased the deposition of collagen fibers, and increased expressions of VEGF and VEGFR2 in the obstructed kidney. These findings indicate that shenkang injection alleviates renal dysfunction and fibrotic changes in mice with renal fibrosis by regulating renal angiogenesis. Video Clip of Methodology: Renal Vasculature by Angiography: 6 min 41 sec: Full Screen Alternate

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来源期刊

Bangladesh Journal of Pharmacology PHARMACOLOGY & PHARMACY-

CiteScore

1.50

自引率

18.80%

发文量

审稿时长

>12 weeks

期刊介绍： Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS). A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements. Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review. Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.