巴戟天的免疫学研究:多糖如何作为佐剂

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2021-01-01 DOI:10.1080/07328303.2021.1954657

Haibo Feng , Hui Zhi , Xin Hu , Yan Yang , Linzi Zhang , Qianqian Liu , Yangyang Feng , Daiyan Wu , Xiaonong Yang

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引用次数: 2

摘要

对巴戟天多糖(MOPS)的理化性质、单糖组成及体外、体内免疫调节作用进行了研究。在体外，MOPS显著促进淋巴细胞增殖，增加IFN-γ和IL-4分泌。在体内，MOPS作为佐剂，显著上调hbsag特异性IgG和IgG同型水平，促进抗原特异性T细胞增殖和细胞因子(IL-2和IL-5)的产生，诱导CTL和NK细胞毒性。此外，MOPS增加了DC成熟。总的来说，MOPS可以作为佐剂通过促进DC成熟来促进体液和细胞免疫反应，这表明MOPS可能具有天然免疫增强剂的潜力。下载:下载高清图片(850KB)下载:下载全尺寸图片

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Immunological studies of Morinda officinalis: How polysaccharides act as adjuvants

Morinda officinalis polysaccharides (MOPS) were investigated for their physicochemical properties, monosaccharide composition, and immune-modulating effects in vitro and in vivo. In vitro, MOPS significantly promoted lymphocyte proliferation and increased IFN-γ and IL-4 secretion. In vivo, MOPS acted as adjuvant, which significantly up-regulated HBsAg-specific IgG and IgG isotype levels, promoted antigen-specific T cell proliferation and cytokine (IL-2 and IL-5) production, and induced CTL and NK cytotoxicity. Moreover, MOPS increased DC maturation. Overall, MOPS can serve as an adjuvant to promote humoral and cellular immune responses via promoting DC maturation, suggesting that MOPS may have potentials as a natural immune-enhancing agent.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.