Progress in the field of hydrotropy: mechanism, applications and green concepts

Abstract Sustainability and greenness are the concepts of growing interest in the area of research as well as industries. One of the frequently encountered challenges faced in research and industrial fields is the solubility of the hydrophobic compound. Conventionally organic solvents are used in various applications; however, their contribution to environmental pollution, the huge energy requirement for separation and higher consumption lead to unsustainable practice. We require solvents that curtail the usage of hazardous material, increase the competency of mass and energy and embrace the concept of recyclability or renewability. Hydrotropy is one of the approaches for fulfilling these requirements. The phenomenon of solubilizing hydrophobic compound using hydrotrope is termed hydrotropy. Researchers of various fields are attracted to hydrotropy due to its unique physicochemical properties. In this review article, fundamentals about hydrotropes and various mechanisms involved in hydrotropy have been discussed. Hydrotropes are widely used in separation, heterogeneous chemical reactions, natural product extraction and pharmaceuticals. Applications of hydrotropes in these fields are discussed at length. We have examined the significant outcomes and correlated them with green engineering and green chemistry principles, which could give an overall picture of hydrotropy as a green and sustainable approach for the above applications.