丹参、利巴诺蒂卡微乳液制剂的设计。亚种。linearis（Bentham）Bornm和Ziziphora斜足类Lam。土耳其提取物及其生物活性的体外评价

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2021-12-31 DOI:10.3906/bot-2108-50

U. Güven

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引用次数: 4

摘要

：多年来，Lamiaceae科的物种一直是一种有用的民间药物。本研究以黄芩（地方病）、利巴韦提（Sideitis libanotica Labill）的提取物为原料，建立了微乳体系。亚种。linearis（Bentham）Bornm（特有）和Ziziphora斜足类Lam。还研究了两者和相关的微乳制剂的潜在生物活性。构建了由油/混合表面活性剂/水乳液体系和四元组分组成的配方的伪三元相图。采用1，1-二苯基-2-苦基肼（DPPH）自由基清除法测定其抗氧化活性。另一方面，为了测定抗菌活性，用大肠杆菌25922、金黄色葡萄球菌29213、白色念珠菌14053和克鲁塞念珠菌6258标准菌株进行微量稀释法。经测试的提取物显示金黄色葡萄球菌特异性抗菌活性，利比亚葡萄球菌亚种的MIC值分别为64µg/mL、256µg/mL和512µg/mL。分别为linearis、S.salvifolia和Z.斜足目。对于任何其他测试菌株，均未观察到相当大的抗菌活性（MIC值>1024µg/mL）。就抗菌活性而言，相关制剂并不优于提取物。所有提取物和相关配方似乎都具有抗氧化活性，并且所有配方的抗氧化能力都高于提取物。当与抗坏血酸相比时，利巴诺蒂卡亚种的配方。linearis提取物具有较强的抗氧化活性。利比亚侧炎亚种。linearis提取物对金黄色葡萄球菌具有显著的抗菌活性。它还具有比抗坏血酸更强的抗氧化能力。此外，所有由提取物开发的配方都具有增强抗氧化活性的特性，尽管它们对抗菌活性没有贡献。总之，考虑到抗氧化活性所带来的潜在抗炎活性，可以预测，尤其是用利巴诺蒂卡亚种开发的制剂。linearis提取物在金黄色葡萄球菌感染的伤口和烧伤的局部治疗中值得探索和进一步研究。

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Design of microemulsion formulations loaded Scutellaria salviifolia Benth, Sideritis libanotica Labill. subsp. linearis (Bentham) Bornm, and Ziziphora clinopodioides Lam. extracts from Turkey and in vitro evaluation of their biological activities

: The species belonging to the Lamiaceae family have been useful tools for many years as a folk remedy. In the present study, a microemulsion system was developed with extract of Scutellaria salviifolia Benth (endemic), Sideritis libanotica Labill. subsp. linearis (Bentham) Bornm (endemic), and Ziziphora clinopodioides Lam. Both and related microemulsion formulations were also investigated for their potential biological activities. Pseudo-ternary phase diagrams of formulations were constructed consisting of oil/ mixed surfactant/water emulsion system and a quaternary component. Antioxidant activity was determined by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging method. For antimicrobial activity determination, on the other hand, microdilution method was performed with Escherichia coli 25922, Staphylococcus aureus 29213, Candida albicans 14053, and Candida krusei 6258 standard strains. Tested extracts showed S. aureus-specific antibacterial activity with MIC values 64 µg/mL, 256 µg/mL, and 512 µg/mL for S. libanotica subsp. linearis, S. salviifolia, and Z. clinopodioides, respectively. For any other tested strain, considerable antimicrobial activity was not observed (MIC values > 1024 µg/mL). Related formulations were not superior to extracts in terms of antimicrobial activity. All extracts and related formulations appear to have antioxidant activity, and the antioxidant capacity of all formulations is higher than the extracts. When compared to ascorbic acid, formulation of S. libanotica subsp. linearis extract has stronger antioxidant activity. Sideritis libanotica subsp. linearis extract had a remarkable antibacterial activity against S. aureus. It also had a stronger antioxidant capacity than ascorbic acid. Besides, all formulations developed from extracts had antioxidant activity enhancing properties, although they did not contribute to antimicrobial activity. In conclusion, considering the potential antiinflammatory activity due to antioxidant activity, it is predicted that especially the formulation developed with Sideritis libanotica subsp. linearis extract is worth exploring with further studies for topical treatment of S. aureus-infected wounds and burns.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.