神经营养因子对TRPV1表达的调节作用：运动抗癫痫作用的可能机制

IF 0.4 Q4 NEUROSCIENCES

Archives of Neuroscience Pub Date : 2023-01-31 DOI:10.5812/ans-134555

Azam Navazesh, Homa Rasoolijazi, Gh Rahmani, Saad Bavi, Gelareh Vahabzadeh, Mansoureh Soleimani, F. Karimzadeh

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引用次数: 0

摘要

背景：癫痫是中枢神经系统最重要的疾病之一，目前尚无明确的治疗方法。神经营养因子可提高神经细胞的存活率，改善神经疾病的治疗。识别影响大脑中神经营养因子增加的因素是大脑健康和功能的重要目标。目的：本研究旨在通过影响香草素受体1型（TRPV1）的表达来研究运动对神经营养因子的影响。方法：运动后5小时注射戊四氮（PTZ；35mg/kg）诱发惊厥。将动物分为五组：假（sham）、癫痫发作（PTZ）、运动（EX）、癫痫诱导运动（EX+PTZ）和癫痫诱导前运动（EX-PTZ）。这项运动是在跑步机上强迫跑30分钟，每周5天，持续四周。结果：与癫痫发作组（PTZ）相比，运动组（EX）、有癫痫发作诱导的运动组（EX+PTZ）和癫痫发作诱导前运动组（EX-PTZ）中NGF细胞的平均百分比以及有癫痫发作诱发的运动组的GDNF有显著增加。此外，与癫痫发作组（PTZ）相比，运动组（EX）、癫痫发作诱导运动组（EX+PTZ）和癫痫发作诱导前运动组（EX-PTZ）的TRPV1活性显著增加。结论：我们的研究结果表明，运动可能通过激活神经营养因子和TRPV1调节来发挥抗癫痫和抗癫痫的作用。

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Modulatory Effect of Neurotrophic Factors on the TRPV1 Expression: Possible Mechanisms Involved in the Antiepileptic Effect of Exercise

Background: Epilepsy is one of the most important diseases of the central nervous system, for which has no definitive treatment. Neurotrophic factors increase the survival of nerve cells and improve the treatment of neurological diseases. Identifying factors that affect the increase of neurotrophins in the brain is an important goal for brain health and function. Objectives: This study aimed to investigate the effectiveness of exercise on neurotrophic factors by influencing the expression of vanilloid receptor type 1 (TRPV1). Methods: Convulsions were induced by injecting pentylenetetrazol (PTZ; 35 mg/kg) five hours after exercise. Animals were divided into five groups: sham (Sham), seizure (PTZ), exercise (EX), exercise with seizure induction (EX+PTZ), and exercise before seizure induction (EX-PTZ). The exercise was 30 minutes of forced running on a treadmill, five days a week for four weeks. Results: The average percentage of NGF cells in the exercise groups (EX), exercise with seizure induction (EX+PTZ), and exercise before seizure induction (EX-PTZ), and GDNF in the exercise group with seizure induction (EX+PTZ) had a significant increase compared to the seizure group (PTZ). Also, TRPV1 activity in exercise groups (EX), exercise with seizure induction (EX+PTZ), and exercise before seizure induction (EX-PTZ) showed a significant increase compared to the seizure group (PTZ). Conclusions: Our findings suggested the possible antiepileptic and antiepileptogenesis effects of exercise through activation of neurotrophic factors and TRPV1 modulation.

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Archives of Neuroscience NEUROSCIENCES-

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期刊介绍： Archives of neuroscience is a clinical and basic journal which is informative to all practitioners like Neurosurgeons, Neurologists, Psychiatrists, Neuroscientists. It is the official journal of Brain and Spinal Injury Research Center. The Major theme of this journal is to follow the path of scientific collaboration, spontaneity, and goodwill for the future, by providing up-to-date knowledge for the readers. The journal aims at covering different fields, as the name implies, ranging from research in basic and clinical sciences to core topics such as patient care, education, procuring and correct utilization of resources and bringing to limelight the cherished goals of the institute in providing a standard care for the physically disabled patients. This quarterly journal offers a venue for our researchers and scientists to vent their innovative and constructive research works. The scope of the journal is as far wide as the universe as being declared by the name of the journal, but our aim is to pursue our sacred goals in providing a panacea for the intractable ailments, which leave a psychological element in the daily life of such patients. This authoritative clinical and basic journal was founded by Professor Madjid Samii in 2012.