中药合剂修复退行性关节的疗效观察

IF 0.1 4区 医学
Haidong Wang, Xiao‐dong Yao, Chengjun Wu
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引用次数: 0

摘要

骨关节炎(OA)是一种由于自身修复能力有限而导致的退行性关节疾病。人们越来越需要新的、更有效的替代品来促进软骨关节再生。天然化合物作为草药是治疗OA的理想药物。为了探索功能性草药,我们研究了草药混合物与骨髓间充质干细胞(BMSCs)一起修复大鼠软骨组织的疗效。将40只SD大鼠随机分为4组。制作了钻孔软骨损伤模型。对组织学H&E分析、Mankin评分和软骨特异性标志物进行测试。我们发现,与对照组相比,草药混合物治疗可以显著改善受损的软骨。此外,草药配方和含有BMSC的3D生物支架的组合可以产生更好的修复受损软骨的功效。我们的数据表明,草药制剂对治疗受损软骨是有效的,草药疗法和骨髓基质干细胞在修复受损软骨组织方面是最有希望的治疗效果,证明了在临床上可以考虑的联合治疗效果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
The Therapeutic Effect of Herbal Mixture in Repairing Degenerated Joint
Osteoarthritis (OA) is a degenerative joint disease due to the limited capacity to repair itself. There is an increasing need for novel and more effective alternatives to promote cartilage joint regeneration. Natural compounds as herbal remedies are ideal to be considered to treat OA. In order to explore the functional herbal remedy, we investigated the efficacy of herbal mixture along with bone mesenchymal stem cells (BMSCs) in repairing rat cartilage tissues. Forty SD rats were randomly divided into four groups. A cartilage injury models by a drilling was made. The histological H&E analysis, Mankin scores and cartilage-specific markers were tested. We found that herbal mixture treatment can significantly improve the damaged cartilage compared to the control. Moreover, the combination of herbal formulation and 3D bioscaffold containing BMSCs can produce better efficacy to repair the damaged cartilages. Our data provides that herbal formulation is effective to treat damaged cartilage, and the herbal remedy along with BMSCs is most promising therapeutic effect in repairing damaged cartilage tissue, demonstrating a combinational therapeutic effect to be considered in the clinic.
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