桔梗中新的β-卡波林和第一个生物碱Plagranline A

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-08-26 DOI:10.25135/rnp.354.2207.2510

Yang Yu, Ju-tao Wang, Lan Ding, Ren-nai Yang, Liang-ping Zha, Shuang Gui

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引用次数: 0

摘要

从桔梗根中分离得到一种新的β-卡波林，即Plagranline A（1）和一种已知的生物碱（2）。结合光谱分析和计算化学，包括电子圆二色性（ECD）和旋光色散（ORD），阐明了它们的结构。生物碱1和2对NO的产生具有中等的抑制作用。有趣的是，1和2是从植物桔梗中报道的第一个生物碱成分。

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Plagranline A, a Novel β-carboline and the First Alkaloid Isolated from Platycodon grandiflorus

: A novel β -carboline, namely Plagranline A ( 1 ), and a known alkaloid ( 2 ) were isolated from the roots of Platycodon grandiflorus . Their structure was elucidated using a combination of spectroscopic analyses and computational chemistry, including electronic circular dichroism (ECD) and optical rotatory dispersion (ORD). Alkaloids 1 and 2 exhibited moderate inhibitory effects against NO production. Interestingly, 1 and 2 are the first alkaloid constituents reported from the plant P. grandifloras.

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来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.