Armaan Fallahi, Giovanni Hernandez, Jose-Maria Restrepo Lozano, Cecilia Flores
{"title":"青少年大麻素对成年期小鼠行为抑制和应激易感性的影响","authors":"Armaan Fallahi, Giovanni Hernandez, Jose-Maria Restrepo Lozano, Cecilia Flores","doi":"10.26443/msurj.v16i1.57","DOIUrl":null,"url":null,"abstract":"Background: Cannabis is one of the most frequently used substances by adolescents. Early exposure to psychoactive compounds has been shown to alter normal brain development and has consequences for psychiatric illness and behaviour in adulthood. In this study, we explored the effects of adolescent synthetic cannabinoid exposure on susceptibility to stress in adulthood, in addition to changes in impulsive behaviour.\nMethods: Chronic treatment with synthetic cannabinoid WIN55,212-2 (WIN) at various doses in adolescent mice was followed by the chronic social defeat stress paradigm in adulthood to assay changes in susceptibility to stress. We then employed the operant Go/No-Go task to investigate changes in impulsivity.\nResults: No changes in susceptibility to stress were identified (χ2(3)=0.585, p=0.900). Strikingly, we demonstrated a dose dependent decrease in impulsivity of adolescent WIN-treated subjects as measured using the Go/No-Go task (F(3, 20)=5.743, p=0.0053).\nLimitations: The main limitation of our findings is the small sample size, particularly for assaying changes in susceptibility to stress using the chronic social defeat stress paradigm. Furthermore, the single housing of animals and suboptimal performance of controls may have affected our findings in the Go/No-Go task.\nConclusion: Overall, this study presents a novel behavioural finding consequent to adolescent exposure to cannabinoids. Further research into the long-term effects of cannabinoid use in adolescence is needed, especially in light of its prevalent use and legalization in Canada.","PeriodicalId":91927,"journal":{"name":"McGill Science undergraduate research journal : MSURJ","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2021-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of adolescent cannabinoid administration in mice on behavioural inhibition and susceptibility to stress during adulthood\",\"authors\":\"Armaan Fallahi, Giovanni Hernandez, Jose-Maria Restrepo Lozano, Cecilia Flores\",\"doi\":\"10.26443/msurj.v16i1.57\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Background: Cannabis is one of the most frequently used substances by adolescents. Early exposure to psychoactive compounds has been shown to alter normal brain development and has consequences for psychiatric illness and behaviour in adulthood. In this study, we explored the effects of adolescent synthetic cannabinoid exposure on susceptibility to stress in adulthood, in addition to changes in impulsive behaviour.\\nMethods: Chronic treatment with synthetic cannabinoid WIN55,212-2 (WIN) at various doses in adolescent mice was followed by the chronic social defeat stress paradigm in adulthood to assay changes in susceptibility to stress. We then employed the operant Go/No-Go task to investigate changes in impulsivity.\\nResults: No changes in susceptibility to stress were identified (χ2(3)=0.585, p=0.900). Strikingly, we demonstrated a dose dependent decrease in impulsivity of adolescent WIN-treated subjects as measured using the Go/No-Go task (F(3, 20)=5.743, p=0.0053).\\nLimitations: The main limitation of our findings is the small sample size, particularly for assaying changes in susceptibility to stress using the chronic social defeat stress paradigm. Furthermore, the single housing of animals and suboptimal performance of controls may have affected our findings in the Go/No-Go task.\\nConclusion: Overall, this study presents a novel behavioural finding consequent to adolescent exposure to cannabinoids. Further research into the long-term effects of cannabinoid use in adolescence is needed, especially in light of its prevalent use and legalization in Canada.\",\"PeriodicalId\":91927,\"journal\":{\"name\":\"McGill Science undergraduate research journal : MSURJ\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2021-04-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"McGill Science undergraduate research journal : MSURJ\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.26443/msurj.v16i1.57\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"McGill Science undergraduate research journal : MSURJ","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.26443/msurj.v16i1.57","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of adolescent cannabinoid administration in mice on behavioural inhibition and susceptibility to stress during adulthood
Background: Cannabis is one of the most frequently used substances by adolescents. Early exposure to psychoactive compounds has been shown to alter normal brain development and has consequences for psychiatric illness and behaviour in adulthood. In this study, we explored the effects of adolescent synthetic cannabinoid exposure on susceptibility to stress in adulthood, in addition to changes in impulsive behaviour.
Methods: Chronic treatment with synthetic cannabinoid WIN55,212-2 (WIN) at various doses in adolescent mice was followed by the chronic social defeat stress paradigm in adulthood to assay changes in susceptibility to stress. We then employed the operant Go/No-Go task to investigate changes in impulsivity.
Results: No changes in susceptibility to stress were identified (χ2(3)=0.585, p=0.900). Strikingly, we demonstrated a dose dependent decrease in impulsivity of adolescent WIN-treated subjects as measured using the Go/No-Go task (F(3, 20)=5.743, p=0.0053).
Limitations: The main limitation of our findings is the small sample size, particularly for assaying changes in susceptibility to stress using the chronic social defeat stress paradigm. Furthermore, the single housing of animals and suboptimal performance of controls may have affected our findings in the Go/No-Go task.
Conclusion: Overall, this study presents a novel behavioural finding consequent to adolescent exposure to cannabinoids. Further research into the long-term effects of cannabinoid use in adolescence is needed, especially in light of its prevalent use and legalization in Canada.