小鼠肠道菌群细菌图谱

IF 2.6 2区生物学 Q3 CELL BIOLOGY

Cellular Microbiology Pub Date : 2021-09-16 DOI:10.21203/rs.3.rs-829178/v1

Mengqi Chu, Xiaobo Zhang

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引用次数: 4

摘要

背景：小鼠模型是探索人类肠道微生物群作用的最广泛使用的动物模型之一，肠道微生物群是一个涉及人类免疫和代谢的复杂系统。然而，小鼠肠道细菌群落的结构尚未得到大规模的探索。为了解决这一问题，本研究对600只小鼠肠道细菌的多样性和组成进行了表征。结果：在所有小鼠个体的肠道微生物群中均发现8属细菌，表明这8种细菌是小鼠肠道微生物群的核心细菌。小鼠肠道细菌的优势属包括15个细菌属。研究发现，肠道微生物群中的细菌主要通过肠道细菌之间的协作参与宿主的代谢。进一步的分析表明，小鼠肠道微生物群的组成与人类肠道微生物群相似。结论：我们的研究提供了小鼠肠道微生物群的细菌图谱，为研究小鼠肠道微生物群落提供了坚实的基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bacterial Atlas of Mouse Gut Microbiota

Background: Mouse model is one of of the most widely used animal models for exploring the roles of human gut microbiota, a complex system involving in human immunity and metabolism. However, the structure of mouse gut bacterial community has not been explored at a large scale. To address this concern, the diversity and composition of the gut bacteria of 600 mice was characterized in this study. Results: The results showed that the bacteria belonging to 8 genera were found in the gut microbiota of all mouse individuals, indicating that the 8 bacteria were the core bacteria of mouse gut microbiota. The dominant genera of the mouse gut bacteria contained 15 bacterial genera. It was found that the bacteria in the gut microbiota were mainly involved in host’s metabolisms via the collaborations between the gut bacteria. The further analysis demonstrated that the composition of mouse gut microbiota was similar to that of human gut microbiota. Conclusion: Our study presented a bacterial atlas of mouse gut microbiota, providing a solid basis for investing the bacterial communities of mouse gut microbiota.

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来源期刊

Cellular Microbiology 生物-微生物学

CiteScore

9.70

自引率

0.00%

发文量

审稿时长

3 months

期刊介绍： Cellular Microbiology aims to publish outstanding contributions to the understanding of interactions between microbes, prokaryotes and eukaryotes, and their host in the context of pathogenic or mutualistic relationships, including co-infections and microbiota. We welcome studies on single cells, animals and plants, and encourage the use of model hosts and organoid cultures. Submission on cell and molecular biological aspects of microbes, such as their intracellular organization or the establishment and maintenance of their architecture in relation to virulence and pathogenicity are also encouraged. Contributions must provide mechanistic insights supported by quantitative data obtained through imaging, cellular, biochemical, structural or genetic approaches.