核蛋白:从结构、功能到疾病发展

IF 2.946 Q3 Biochemistry, Genetics and Molecular Biology

BMC Molecular Biology Pub Date : 2016-08-24 DOI:10.1186/s12867-016-0073-9

Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne, Derek J. Richard

{"title":"核蛋白:从结构、功能到疾病发展","authors":"Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne, Derek J. Richard","doi":"10.1186/s12867-016-0073-9","DOIUrl":null,"url":null,"abstract":"<p>Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.</p>","PeriodicalId":497,"journal":{"name":"BMC Molecular Biology","volume":"17 1","pages":""},"PeriodicalIF":2.9460,"publicationDate":"2016-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1186/s12867-016-0073-9","citationCount":"180","resultStr":"{\"title\":\"Nucleophosmin: from structure and function to disease development\",\"authors\":\"Joseph K. Box, Nicolas Paquet, Mark N. Adams, Didier Boucher, Emma Bolderson, Kenneth J. O’Byrne, Derek J. Richard\",\"doi\":\"10.1186/s12867-016-0073-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.</p>\",\"PeriodicalId\":497,\"journal\":{\"name\":\"BMC Molecular Biology\",\"volume\":\"17 1\",\"pages\":\"\"},\"PeriodicalIF\":2.9460,\"publicationDate\":\"2016-08-24\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.1186/s12867-016-0073-9\",\"citationCount\":\"180\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"BMC Molecular Biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://link.springer.com/article/10.1186/s12867-016-0073-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Biochemistry, Genetics and Molecular Biology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"BMC Molecular Biology","FirstCategoryId":"1085","ListUrlMain":"https://link.springer.com/article/10.1186/s12867-016-0073-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Biochemistry, Genetics and Molecular Biology","Score":null,"Total":0}

引用次数: 180

摘要

核磷蛋白(nuclear ophosmin, NPM1)是一种重要的细胞蛋白，参与mRNA转运、染色质重塑、细胞凋亡和基因组稳定性等多种途径。NPM1功能是正常细胞生物学的关键要求，正如在癌症中强调的那样，NPM1通常过表达、突变、重排和偶尔缺失。与细胞内的多功能作用一致，NPM1不仅可以作为原癌基因，还可以作为肿瘤抑制基因。这篇综述的目的是研究NPM1在DNA修复途径中的作用，以及NPM1在癌症细胞凋亡及其突变的调节中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Nucleophosmin: from structure and function to disease development

查看原文本刊更多论文

Nucleophosmin: from structure and function to disease development

Nucleophosmin (NPM1) is a critical cellular protein that has been implicated in a number of pathways including mRNA transport, chromatin remodeling, apoptosis and genome stability. NPM1 function is a critical requirement for normal cellular biology as is underlined in cancer where NPM1 is commonly overexpressed, mutated, rearranged and sporadically deleted. Consistent with a multifunctional role within the cell, NPM1 can function not only as a proto-oncogene but also as a tumor suppressor. The aim of this review is to look at the less well-described role of NPM1 in the DNA repair pathways as well as the role of NPM1 in the regulation of apoptosis and its mutation in cancers.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

BMC Molecular Biology 生物-生化与分子生物学

CiteScore

4.80

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： BMC Molecular Biology is an open access journal publishing original peer-reviewed research articles in all aspects of DNA and RNA in a cellular context, encompassing investigations of chromatin, replication, recombination, mutation, repair, transcription, translation and RNA processing and function.