Liza A. Wijler, Daniëlle A. E. Raats, A. Verheem, A. Otter, H. Rundqvist, M. Dijk, A. May, O. Kranenburg
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Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model
Physical activity is associated with a lower risk of colorectal cancer (CRC) and CRC‐specific mortality. However, evidence for a causal relationship between physical activity and disease progression is lacking. Here, we have used CRC organoids to create a novel mouse model for spontaneous metastasis formation to multiple organs. We have used this model to assess the influence of voluntary exercise on disease progression.
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