Juan Corredoira Sánchez , Blanca Ayuso García , Eva María Romay Lema , María José García-Pais , Ana I. Rodríguez-Macias , Patricia Capón González , Rocio Otero López , Ramón Rabuñal Rey , Pilar Alonso García
{"title":"成人中枢神经系统牛链球菌感染:4例报告及文献复习。","authors":"Juan Corredoira Sánchez , Blanca Ayuso García , Eva María Romay Lema , María José García-Pais , Ana I. Rodríguez-Macias , Patricia Capón González , Rocio Otero López , Ramón Rabuñal Rey , Pilar Alonso García","doi":"10.1016/j.eimc.2022.06.010","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><p>To describe the clinical features, history and association with intestinal disease in central nervous system (CNS) <em>S. bovis</em> infections.</p></div><div><h3>Methods</h3><p>Four cases of <em>S. bovis</em> CNS infections from our institution are presented. Additionally a systematic literature review of articles published between 1975 and 2021 in PubMed/MEDLINE was conducted.</p></div><div><h3>Results</h3><p>52 studies with 65 cases were found; five were excluded because of incomplete data. In total 64 cases were analyzed including our four cases: 55 with meningitis and 9 with intracranial focal infections. Both infections were frequently associated with underlying conditions (70.3%) such as immunosuppression (32.8%) or cancer (10.9%). In 23 cases a biotype was identified, with biotype <span>II</span> being the most frequent (69.6%) and <em>S. pasteurianus</em> the most common within this subgroup. Intestinal diseases were found in 60.9% of cases, most commonly neoplasms (41.0%) and <span><em>Strongyloides</em></span> infestation (30.8%). Overall mortality was 17.1%, with a higher rate in focal infection (44.4% <em>vs</em> 12.7%; <em>p</em> <!-->=<!--> <!-->0.001).</p></div><div><h3>Conclusions</h3><p>CNS infections due to <em>S. bovis</em><span> are infrequent and the most common clinical form is meningitis. Compared with focal infections, meningitis had a more acute course, was less associated with endocarditis and had a lower mortality. Immunosuppression and intestinal disease were frequent in both infections.</span></p></div>","PeriodicalId":11608,"journal":{"name":"Enfermedades infecciosas y microbiologia clinica","volume":null,"pages":null},"PeriodicalIF":2.6000,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Streptococcus bovis infection of the central nervous system in adults: Report of 4 cases and literature review\",\"authors\":\"Juan Corredoira Sánchez , Blanca Ayuso García , Eva María Romay Lema , María José García-Pais , Ana I. Rodríguez-Macias , Patricia Capón González , Rocio Otero López , Ramón Rabuñal Rey , Pilar Alonso García\",\"doi\":\"10.1016/j.eimc.2022.06.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><p>To describe the clinical features, history and association with intestinal disease in central nervous system (CNS) <em>S. bovis</em> infections.</p></div><div><h3>Methods</h3><p>Four cases of <em>S. bovis</em> CNS infections from our institution are presented. Additionally a systematic literature review of articles published between 1975 and 2021 in PubMed/MEDLINE was conducted.</p></div><div><h3>Results</h3><p>52 studies with 65 cases were found; five were excluded because of incomplete data. In total 64 cases were analyzed including our four cases: 55 with meningitis and 9 with intracranial focal infections. Both infections were frequently associated with underlying conditions (70.3%) such as immunosuppression (32.8%) or cancer (10.9%). In 23 cases a biotype was identified, with biotype <span>II</span> being the most frequent (69.6%) and <em>S. pasteurianus</em> the most common within this subgroup. Intestinal diseases were found in 60.9% of cases, most commonly neoplasms (41.0%) and <span><em>Strongyloides</em></span> infestation (30.8%). Overall mortality was 17.1%, with a higher rate in focal infection (44.4% <em>vs</em> 12.7%; <em>p</em> <!-->=<!--> <!-->0.001).</p></div><div><h3>Conclusions</h3><p>CNS infections due to <em>S. bovis</em><span> are infrequent and the most common clinical form is meningitis. Compared with focal infections, meningitis had a more acute course, was less associated with endocarditis and had a lower mortality. Immunosuppression and intestinal disease were frequent in both infections.</span></p></div>\",\"PeriodicalId\":11608,\"journal\":{\"name\":\"Enfermedades infecciosas y microbiologia clinica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Enfermedades infecciosas y microbiologia clinica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0213005X22001549\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"INFECTIOUS DISEASES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Enfermedades infecciosas y microbiologia clinica","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0213005X22001549","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}
Streptococcus bovis infection of the central nervous system in adults: Report of 4 cases and literature review
Objectives
To describe the clinical features, history and association with intestinal disease in central nervous system (CNS) S. bovis infections.
Methods
Four cases of S. bovis CNS infections from our institution are presented. Additionally a systematic literature review of articles published between 1975 and 2021 in PubMed/MEDLINE was conducted.
Results
52 studies with 65 cases were found; five were excluded because of incomplete data. In total 64 cases were analyzed including our four cases: 55 with meningitis and 9 with intracranial focal infections. Both infections were frequently associated with underlying conditions (70.3%) such as immunosuppression (32.8%) or cancer (10.9%). In 23 cases a biotype was identified, with biotype II being the most frequent (69.6%) and S. pasteurianus the most common within this subgroup. Intestinal diseases were found in 60.9% of cases, most commonly neoplasms (41.0%) and Strongyloides infestation (30.8%). Overall mortality was 17.1%, with a higher rate in focal infection (44.4% vs 12.7%; p = 0.001).
Conclusions
CNS infections due to S. bovis are infrequent and the most common clinical form is meningitis. Compared with focal infections, meningitis had a more acute course, was less associated with endocarditis and had a lower mortality. Immunosuppression and intestinal disease were frequent in both infections.
期刊介绍:
Hoy está universalmente reconocida la renovada y creciente importancia de la patología infecciosa: aparición de nuevos agentes patógenos, de cepas resistentes, de procesos con expresión clínica hasta ahora desconocida, de cuadros de una gran complejidad. Paralelamente, la Microbiología y la Infectología Clínicas han experimentado un gran desarrollo como respuesta al reto planteado por la actual patología infecciosa. Enfermedades Infecciosas y Microbiología Clínica es la Publicación Oficial de la Sociedad Española SEIMC. Cumple con la garantía científica de esta Sociedad, la doble función de difundir trabajos de investigación, tanto clínicos como microbiológicos, referidos a la patología infecciosa, y contribuye a la formación continuada de los interesados en aquella patología mediante artículos orientados a ese fin y elaborados por autores de la mayor calificación invitados por la revista.