肝内胆管癌靶向治疗进展

Q4 Medicine

中华肝胆外科杂志 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1007-8118.2019.12.019

Yeming Zhou, Wei Jiang, Jing Huang, Y. Hua, Caide Lu

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引用次数: 0

摘要

肝内胆管癌的发病率逐年上升。对于大多数患者来说，当他们被诊断为ICC时，手术切除是不合适的。常规化疗和放疗对ICC患者的长期生存率无效，并导致不良的整体预后。近年来，随着对胆道恶性肿瘤分子机制认识的加深，一些与ICC发病机制相关的关键基因和信号通路被发现，为靶向治疗提供了新的思路。本文综述了ICC的主要分子机制和靶向治疗。关键词：胆管肿瘤；胆管癌；肝内胆管癌；分子靶向治疗；进度

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Progress of targeted therapy of intrahepatic cholangiocarcinoma

The incidence of intrahepatic cholangiocarcinoma (ICC) has been increasing year by year. For most patients, surgical resection is not suitable when they are diagnosed as ICC. Conventional chemotherapy and radiotherapy are not effective for the long-term survival rate of ICC patients and lead to the poor overall prognosis. In recent years, with the deepening understanding about the molecular mechanism of biliary malignant tumors, some key genes and signaling pathways related to the pathogenesis of ICC have been identified, providing new ideas for the targeted therapy. In this paper, major molecular mechanisms and targeted therapies of ICC are reviewed. Key words: Bile duct neoplasm; Cholangiocarcinoma; Intrahepatic cholangiocarcinoma; Molecular targeted therapy; Progress

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来源期刊

中华肝胆外科杂志 Medicine-Gastroenterology

CiteScore

0.20

自引率

0.00%

发文量

7101

期刊介绍： Chinese Journal of Hepatobiliary Surgery is an academic journal organized by the Chinese Medical Association and supervised by the China Association for Science and Technology, founded in 1995. The journal has the following columns: review, hot spotlight, academic thinking, thesis, experimental research, short thesis, case report, synthesis, etc. The journal has been recognized by Beida Journal (Chinese Journal of Humanities and Social Sciences). Chinese Journal of Hepatobiliary Surgery has been included in famous databases such as Peking University Journal (Chinese Journal of Humanities and Social Sciences), CSCD Source Journals of China Science Citation Database (with Extended Version) and so on, and it is one of the national key academic journals under the supervision of China Association for Science and Technology.