钙保护蛋白在良恶性胸腔积液鉴别中的诊断价值

IF 1 Q4 RESPIRATORY SYSTEM
Omar Mohammed, K. Hussein, Abdelgawad Ramadan, Goudarzi Mahmoud, M. El-Naggar, Nor Eldein Gaber
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引用次数: 1

摘要

背景胸腔积液可由50多种公认的病因引起,鉴别胸腔积液的良性和恶性来源仍然是一个诊断挑战。肿瘤标志物和其他生物标志物更好地诊断恶性胸腔积液(MPE)的能力仍然值得怀疑。其中,钙相关蛋白S100-A8和S100-A9(非共价异二聚钙卫蛋白)在恶性胸腔积液中有少量表达,而在良性胸腔积液中没有。目的本研究旨在评估钙卫蛋白在鉴别感染性或良性MPE中的诊断价值。患者和方法将60例患者分为I组:恶性胸腔积液和II组:感染性胸腔积液(又分为IIA组:肺旁积液和IIB组:结核性胸腔积液),采用酶联免疫吸附法对胸腔积液中钙卫蛋白进行定量测定。结果MPEs胸膜钙卫蛋白水平(229.2±168.6) ng/ml)显著低于感染性胸腔积液的水平(3202.2±1304.8) ng/ml;P<0.001)。钙卫蛋白水平诊断MPE的临界值小于或等于730.5 结论钙卫蛋白是鉴别恶性胸腔积液和感染性胸腔积液的一种有价值的生物标志物。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Diagnostic value of calprotectin in differentiation between benign and malignant pleural effusion
Background Pleural effusion can arise as a result of more than 50 recognized causes and the differentiation between benign and malignant origin of the fluid is still a diagnostic challenge. The ability of tumor markers and other biological markers to make better diagnosis of malignant pleural effusion (MPE) remains questionable. Out of these, the calcium-related proteins S100-A8 and S100-A9 (the noncovalent heterodimer calprotectin) were demonstrated in a small amount in malignant not in benign pleural effusion. Objectives This research aimed to assess the diagnostic value of calprotectin in the differentiation between infectious or benign and MPE. Patients and methods Sixty patients were divided into group I: malignant and group II: infectious pleural effusions (which were further divided into group IIA: parapneumonic effusion and group IIB: tuberculous effusion) Quantitative measurement of calprotectin was done using the enzyme-linked immunosorbent assay technique in pleural effusion. Results Pleural calprotectin level in MPEs (229.2±168.6 ng/ml) was significantly lower than its level of infectious pleural effusions (3202.2±1304.8 ng/ml; P<0.001). The cutoff value of calprotectin level for the diagnosis of MPE was less than or equal to 730.5 ng/ml, with 95% confidence interval and the area under the curve was 0.999, the corresponding sensitivity was 96.7 and the specificity was 100% (P<0.001). Conclusion Calprotectin is a valuable biomarker in differentiating malignant from infectious pleural effusion.
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来源期刊
Egyptian Journal of Bronchology
Egyptian Journal of Bronchology RESPIRATORY SYSTEM-
自引率
7.70%
发文量
56
审稿时长
9 weeks
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