番木瓜籽对糖尿病诱导的大鼠认知能力下降的神经保护和促神经活性

Q4 Pharmacology, Toxicology and Pharmaceutics

Iranian Journal of Pharmaceutical Sciences Pub Date : 2018-07-01 DOI:10.22034/IJPS.2019.35934

V. Eggadi, srilatha keshaveni, S. Bandaru, U. Kulandaivelu

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引用次数: 4

摘要

本研究的目的是研究番木瓜籽石油醚提取物（PEECPS）对糖尿病诱导的认知能力下降大鼠的神经保护和促神经活性。采用矩形迷宫和morris水迷宫模型，通过测定糖尿病大鼠脑内乙酰胆碱酯酶（AchE）、丙二醛（MDA）、超氧化物歧化酶（SOD）、一氧化氮（NO）、过氧化氢酶（CAT）和谷胱甘肽（GSH）水平，研究其促神经活动和神经保护作用。在矩形迷宫和morris水迷宫模型中，在第75天，与糖尿病对照组相比，400mg/kg的PECPS显示出显著效果。与糖尿病对照组相比，PECPS（200和400mg/kg）可显著降低AchE（P<0.001）、MDA（P<0.01）、NO（P<0.05），并显著提高SOD、CAT和GSH水平（P<0.01）。有必要对番木瓜种子进行进一步的研究，因为它可以预防糖尿病引起的认知能力下降，以揭示其作用模式。

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Neuroprotective and nootropic activity of Carica papaya seeds on Diabetes induced cognitive decline in rats

The aim of present study is to investigate neuroprotective and nootropic activity of Petroleum Ether Extract of Carica papaya seeds (PEECPS) on diabetic induced cognitive decline rats. Rectangular maze and morris water maze models were used to evaluate nootropic activity and neuroprotective effects were studied by estimating acetyl cholinesterase (AchE), malondialdehyde (MDA), superoxide dismutase (SOD), nitric oxide (NO), catalase (CAT) and glutathione (GSH) levels in the brains of diabetic rats. In rectangular maze and morris water maze models, 400 mg/kg of PECPS were shown the significant effect when compared with diabetic control on day 75. Significant decrease in AchE (P<0.001), MDA (P<0.01), NO (P<0.05) and significantly (P<0.01) increased levels of SOD, CAT and GSH with PECPS (200 and 400 mg/kg) when compared with diabetic control. There is a need of further studies on Carica papaya seeds as it showed protection against diabetes induced cognitive decline to reveal its mode of action.

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来源期刊

Iranian Journal of Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.50

自引率

0.00%

发文量

期刊介绍： Iranian Journal of Pharmaceutical Sciences (IJPS) is an open access, internationally peer-reviewed journal that seeks to publish research articles in different pharmaceutical sciences subdivisions: pharmacology and toxicology, nanotechnology, pharmaceutics, natural products, biotechnology, pharmaceutical chemistry, clinical pharmacy and other pharmacy related topics. Each issue of the journal contents 16 outstanding research articles in area of pharmaceutical sciences plus an editorial written by the IJPS editors on one of the most up to date advances topics in pharmacy. All articles published by IJPS would be permanently accessible online freely without any subscription charges. Authors of the published articles have granted the right to use and disseminate their article to third parties.