LincRNA-p21在肿瘤中的研究进展

国际生物医学工程杂志 Pub Date : 2019-10-28 DOI:10.3760/CMA.J.ISSN.1673-4181.2019.05.011

Jing Wu

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引用次数: 0

摘要

长链非编码RNA（LncRNA）长度超过200个核苷酸，不能编码蛋白质。它具有多种生物学功能。大量研究表明，LncRNA与癌症的发生发展密切相关。分子生物学水平的研究发现，LncRNA是一种重要的调控分子，参与生命活动的全过程，在各种疾病和肿瘤中发挥调控作用。LincRNA-p21是一种新型的LncRNA，通过靶向mRNA或引导蛋白质结合伴侣的染色质位点来发挥翻译抑制剂的作用。LincRNA-p21与多种肿瘤密切相关，并通过不同途径发挥其致癌或抑瘤的生物学功能。本文综述了肿瘤相关基因LincRNA-p21的研究进展。关键词：非编码RNA；长基因间非编码RNA；LncRNA-p21；肿瘤

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Research progress of LincRNA-p21 in tumors

Long-chain non-coding RNA (LncRNA) has more than 200 nucleotides in length and cannot encode proteins. It has a variety of biological functions. A large number of studies have shown that LncRNA is closely related to the occurrence and development of cancer. Researches at the level of molecular biology have found that LncRNA acts as an important regulatory molecule involved in the whole process of life activities and plays a regulatory role in various diseases and tumors. LincRNA-p21 is a novel LncRNA that acts as a translational inhibitor by targeting mRNA or by directing the chromatin site of a protein-binding partner. LincRNA-p21 is closely related to a variety of tumors and exerts its biological functions of carcinogenesis or tumor suppression through different pathways. In this paper, the research progress of the tumor-associated gene LincRNA-p21 was reviews Key words: Non-coding RNA; Long intergenic non-coding RNA; LncRNA-p21; Tumor

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来源期刊

国际生物医学工程杂志

自引率

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1974