利马La Victoria地区抗结核药物耐药性的流行病学概况

UCVScientia Pub Date : 2018-01-15 DOI:10.18050/REVUCV-SCIENTIA.V9N2A7

Oriana Rivera Lozada, César Antonio Bonilla Asalde

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引用次数: 0

摘要

西班牙-秘鲁是一个结核病负担沉重、耐药形式普遍存在的国家。这项研究的目的是确定研究期间在维多利亚区卫生机构接受治疗的FP-TBP患者对抗结核药物耐药性的流行病学概况。进行了一项横向剪切型观测研究。在维多利亚区招募职业性肺结核病例。分析包括120例病例，其中86例（71.7%）没有治疗史，34例（28.3%）有治疗史。81人为男性（67.5%）和39人为女性（32.5%）。NT对一种或多种药物的耐药性为21%，AT为41.2%。链霉素在新病例和治疗前的单药耐药性最高。MDR模式出现在35.2%的TA和4.6%的NT中。研究表明，利马市维多利亚区的初始MDR结核病负担很高，继发耐药性的患病率很高。英语秘鲁是一个结核病负担沉重、耐药形式普遍存在的国家。这项研究的目的是确定在研究期间在维多利亚区卫生设施接受治疗的PPB-TB患者对结核病药物耐药性的流行病学预防。进行了一项观察性的跨部门研究。在维多利亚区招募了TBP FP病例。分析中包括120例病例，其中86例（71.7%）没有治疗史，34例（28.3%）有治疗史。81人为男性（67.5%）和39人为女性（32.5%）。NT对一种或多种药物的耐药性为21%，TA为41.2%。链霉素在新的和以前治疗的病例中都获得了最高的单药耐药性。耐多药模式分别占TA的35.2%和NT的4.6%。研究表明，利马市维多利亚-迪萨区的初始耐多药结核病负担很高，二次耐药率很高

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Perfil epidemiológico de las resistencias a fármacos antituberculosis en el distrito de La Victoria, Lima

espanolEl Peru es un pais con elevada carga de enfermedad tuberculosa y alta prevalencia de sus formas resistentes. El estudio tuvo como finalidad Determinar el perfil epidemiologico de la Resistencia a farmacos antituberculosis en pacientes con TBP FP que son atendidos en los establecimientos de salud del distrito de La Victoria durante el periodo de estudio. Se realizo un estudio observacional de tipo Corte Transversal. Donde se recluto casos de TBP FP en el distrito La Victoria. Se incluyeron en el analisis 120 casos de los cuales 86 (71.7%) no tenian antecedentes de tratamiento (NT) y 34 (28.3%) tenian antecedentes de tratamiento (AT). 81 fueron varones (67.5%) y 39 mujeres (32.5%). La Resistencia a uno o mas medicamentos fue de 21% en los NT y de 41.2% en los AT. La Estreptomicina obtuvo el valor mas alto de monorresistencia tanto en casos nuevos como en antes tratados. El patron MDR se presento en 35.2% de los AT y 4.6% de los NT. El estudio evidencio que el distrito de La Victoria de la DISA V Lima Ciudad tiene una alta carga de TB MDR inicial, con una alta prevalencia de Resistencia secundaria. EnglishPeru is a country with a high burden of tuberculosis disease and high prevalence of its resistant forms. The purpose of the study was to determine the epidemiological profile of resistance to anti-tuberculosis drugs in patients with PPB-TB who are treated at the health facilities of the district of La Victoria during the study period. An observational cross-sectional study was performed. Where cases of TBP FP were recruited in the La Victoria district. 120 cases were included in the analysis, of which 86 (71.7%) had no history of treatment and 34 (28.3%) had a history of treatment (NT). 81 were men (67.5%) and 39 women (32.5%). Resistance to one or more drugs was 21% in the NT and 41.2% in the TA. Streptomycin obtained the highest value of monoresistance in both new and previously treated cases. The MDR pattern was present in 35.2% of AT and 4.6% of NT.The study showed that the district of La Victoria DISA V Lima City has a high initial MDR TB burden, with a high prevalence of secondary resistance

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UCVScientia

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12 weeks