7SK snRNP复合物组装和功能的结构基础

Aditi N. Borkar, Iván D’Orso
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引用次数: 4

摘要

RNA在精确控制包括转录、翻译和DNA复制在内的几个生物过程中发挥着核心作用。因此,RNA介导的过程的正确功能对于维持细胞稳态从而避免恶性肿瘤至关重要。Feigon及其同事最近对人LARP7及其在7SK RNA上的结合位点的结构进行了研究(1),揭示了这种蛋白质-RNA相互作用如何促进7SK RNA识别的分子细节,并为正确的转录控制提供了对7SK小核核糖核蛋白(snRNP)复合物组装的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Structural basis for assembly and function of the 7SK snRNP complex
RNA plays a central role in the precise control of several biological processes including transcription, translation and DNA replication. As such, correct function of RNA-mediated processes is vital for maintaining cell homeostasis thereby avoiding malignancy. The recent structure of human LARP7 and its binding site on 7SK RNA by Feigon and co-workers (1) reveals molecular details into how this protein-RNA interaction contributes to 7SK RNA recognition and provides insights into the assembly of the 7SK small nuclear ribonucleoprotein (snRNP) complex for correct transcriptional control.
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