脂肪组织老化部分解释了HIV脂肪营养不良中脂肪的改变

IF 3.5 4区生物学 Q2 ENDOCRINOLOGY & METABOLISM

Adipocyte Pub Date : 2022-03-17 DOI:10.1080/21623945.2022.2042962

P. Domingo, M. Giralt, A. Gavaldà-Navarro, A. Blasco-Roset, Alejandro Delgado-Anglés, J. M. Gallego-Escuredo, M. Gutiérrez, M. Mateo, R. Cereijo, J. Domingo, F. Villarroya, J. Villarroya

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引用次数: 1

摘要

脂肪营养不良是HIV-1 (PLWH)患者的主要障碍。PLWH的一些系统性改变与衰老过程中发生的变化相似。目前尚不清楚PLWH中的脂肪营养不良是否是脂肪组织加速老化的结果。我们比较了PLWH患者与健康老年人(~80岁)的全身和脂肪组织紊乱。我们在老年人和PLWH的脂肪组织中观察到类似的炎症相关基因表达增强和自噬减少。脂肪生成抑制和线粒体功能障碍的迹象是PLWH特有的，而端粒长度减少和衰老的迹象是老年人特有的。我们得出结论，脂肪组织的老化仅部分解释了PLWH脂肪组织的改变。

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Adipose tissue aging partially accounts for fat alterations in HIV lipodystrophy

ABSTRACT Lipodystrophy is a major disturbance in people living with HIV-1 (PLWH). Several systemic alterations in PLWH are reminiscent of those that occur in ageing. It is unknown whether the lipodystrophy in PLWH is the consequence of accelerated ageing in adipose tissue. We compared systemic and adipose tissue disturbances in PLWH with those in healthy elderly individuals (~80 y old). We observed similarly enhanced expression of inflammation-related genes and decreased autophagy in adipose tissues from elderly individuals and PLWH. Indications of repressed adipogenesis and mitochondrial dysfunction were found specifically in PLWH, whereas reduced telomere length and signs of senesce were specific to elderly individuals. We conclude that ageing of adipose tissue accounts only partially for the alterations in adipose tissues of PLWH.

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来源期刊

Adipocyte Medicine-Histology

CiteScore

6.50

自引率

3.00%

发文量

审稿时长

32 weeks

期刊介绍： Adipocyte recognizes that the adipose tissue is the largest endocrine organ in the body, and explores the link between dysfunctional adipose tissue and the growing number of chronic diseases including diabetes, hypertension, cardiovascular disease and cancer. Historically, the primary function of the adipose tissue was limited to energy storage and thermoregulation. However, a plethora of research over the past 3 decades has recognized the dynamic role of the adipose tissue and its contribution to a variety of physiological processes including reproduction, angiogenesis, apoptosis, inflammation, blood pressure, coagulation, fibrinolysis, immunity and general metabolic homeostasis. The field of Adipose Tissue research has grown tremendously, and Adipocyte is the first international peer-reviewed journal of its kind providing a multi-disciplinary forum for research focusing exclusively on all aspects of adipose tissue physiology and pathophysiology. Adipocyte accepts high-profile submissions in basic, translational and clinical research.