V. Zhabinskii, Alexey M. Matorin, O. Savinova, E. Boreko, Academician Vladimir A. Khripach, Член-корреспондент В. Н. Жабинский, А. М. Маторин, О.В. Савинова, Е.И. Бореко, В. А. Хрипач
{"title":"油菜素甾体的抗冠状病毒特性","authors":"V. Zhabinskii, Alexey M. Matorin, O. Savinova, E. Boreko, Academician Vladimir A. Khripach, Член-корреспондент В. Н. Жабинский, А. М. Маторин, О.В. Савинова, Е.И. Бореко, В. А. Хрипач","doi":"10.29235/1561-8323-2023-67-4-295-299","DOIUrl":null,"url":null,"abstract":"Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.","PeriodicalId":41825,"journal":{"name":"DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI","volume":" ","pages":""},"PeriodicalIF":0.1000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Anti-coronavirus properties of brassinosteroids\",\"authors\":\"V. Zhabinskii, Alexey M. Matorin, O. Savinova, E. Boreko, Academician Vladimir A. Khripach, Член-корреспондент В. Н. Жабинский, А. М. Маторин, О.В. Савинова, Е.И. Бореко, В. А. Хрипач\",\"doi\":\"10.29235/1561-8323-2023-67-4-295-299\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.\",\"PeriodicalId\":41825,\"journal\":{\"name\":\"DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.1000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.29235/1561-8323-2023-67-4-295-299\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"DOKLADY NATSIONALNOI AKADEMII NAUK BELARUSI","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.29235/1561-8323-2023-67-4-295-299","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Antiviral properties of natural brassinosteroids of the campestane, ergostane, and stigmastane series (6-ketones and B-lactones) and their (22S,23S)-analogs were studied using the seasonal human respiratory alpha-coronavirus 229E (HCoV-229E) as an example. The presence of anticoronavirus properties was shown for a number of studied compounds. In general, 6-ketones were more active than B-lactones. The maximum inhibitory effect (EC50 21.1 µM) in relation to the reproduction of HCoV-229E was noted for (22S,23S)-epicastasterone.
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