Gross hematuria associated with oral isotretinoin treatment in a young patient with acne vulgaris

Hematuria is defined as the presence of red blood cells in the urine and it may be observed microscopic or gross. Hematuria may originate from any site throughout the urinary tract, the glomerulus and interstitium or renal vasculature. Here, we present a 17-year-old boy who developed terminal hematuria after two months of treatment with isotretinoin for acne vulgaris. Radiological and cystoscopic assessment of the urinary system were normal. Isotretinoin treatment was stopped after dermatology consultation. In two weeks, terminal hematuria disappeared along with the dysuria, and the urine sample showed normal findings. Keywords: Acne vulgaris, adverse effect, gross hematuria, isotretinoin.