氧化锌纳米颗粒的合成及其作为药物载体治疗白血病的研究

IF 1 Q4 CHEMISTRY, MULTIDISCIPLINARY

Indonesian Journal of Chemistry Pub Date : 2023-08-15 DOI:10.22146/ijc.82208

Areej. A. Jarullah, Nidhal Meteab Khamees, T. Musa

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引用次数: 0

摘要

本研究包括两个部分，第一部分是通过N-[4-（5-{（Z）-[（5-氧代-2-硫烷基-4,5-二氢-1H-咪唑-1-基）亚氨基]甲基}呋喃-2-基）苯基]乙酰胺与ZnCl2反应制备Zn（II）配合物。通过紫外-可见光谱、LC-MS、FTIR分光光度计、电导率、磁化率和原子吸收等微观分析对配合物进行了表征。第二部分是通过将Zn（II）络合物溶解在HNO3和HCl中制备ZnO纳米颗粒，并将其用作治疗白血病的药物转运蛋白。对ZnO纳米颗粒的FSEM、TEM和XRD进行了表征，这些纳米颗粒将用于未来大多数药物的合成。

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Synthesis of ZnO Nanoparticle and Utilized as a Drug Carrier to Treat Leukemia

This study includes two parts, and the first was the preparation of the Zn(II)complex by reacting N-[4-(5-{(Z)-[(5-oxo-2-sulfanyl-4,5-dihydro-1H-imidazol-1-yl)imino]methyl}furan-2-yl)phenyl]acetamide with ZnCl2. The complex was characterized by using microscopic analysis such as UV-Vis spectrum, LC-MS, FTIR spectrophotometer, measurements of conductivity, magnetic susceptibility, and atomic absorption. The second part was the preparation of the ZnO nanoparticles by dissolving the Zn(II) complex in HNO3 and HCl and its use as a drug transporter to treat leukemia. FSEM, TEM, and XRD were examined for the characterization of ZnO nanoparticles that will be used in the synthesis of most medicines and drugs in the future.

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来源期刊

Indonesian Journal of Chemistry CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

2.30

自引率

11.10%

发文量

106

审稿时长

15 weeks

期刊介绍： Indonesian Journal of Chemistry is a peer-reviewed, open access journal that publishes original research articles, review articles, as well as short communication in all areas of chemistry, including educational chemistry, applied chemistry, and chemical engineering.