{"title":"含羞草叶治疗大鼠溃疡性结肠炎的潜力","authors":"Bharati B Zaware, R. Gilhotra, S. Chaudhari","doi":"10.3329/BJP.V13I3.35648","DOIUrl":null,"url":null,"abstract":"<p class=\"Abstract\">The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of <em>Mimosa pudica</em>. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with <em>M. pudica</em> ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of <em>M. pudica</em> leaf is effective in the treatment of ulcerative colitis.</p><p class=\"Abstract\"><strong>Video Clip of Methodology:</strong></p><p class=\"Abstract\">Embedding or block making: 24 sec <a href=\"https://www.youtube.com/v/Y1I4tKYMLsE\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=Y1I4tKYMLsE\">Alternate</a></p><p class=\"Abstract\">Tissue processing: 19 sec <a href=\"https://www.youtube.com/v/7nYpxL2qPhg\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=7nYpxL2qPhg\">Alternate</a></p><p class=\"Abstract\">Section cutting: 33 sec <a href=\"https://www.youtube.com/v/_amFL9kNLBw\">Full Screen</a> <a href=\"https://www.youtube.com/watch?v=_amFL9kNLBw\">Alternate</a></p>","PeriodicalId":8719,"journal":{"name":"Bangladesh Journal of Pharmacology","volume":" ","pages":""},"PeriodicalIF":0.9000,"publicationDate":"2018-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.3329/BJP.V13I3.35648","citationCount":"4","resultStr":"{\"title\":\"Potential of Mimosa pudica leaf in the treatment of ulcerative colitis in rat\",\"authors\":\"Bharati B Zaware, R. Gilhotra, S. Chaudhari\",\"doi\":\"10.3329/BJP.V13I3.35648\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p class=\\\"Abstract\\\">The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of <em>Mimosa pudica</em>. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with <em>M. pudica</em> ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of <em>M. pudica</em> leaf is effective in the treatment of ulcerative colitis.</p><p class=\\\"Abstract\\\"><strong>Video Clip of Methodology:</strong></p><p class=\\\"Abstract\\\">Embedding or block making: 24 sec <a href=\\\"https://www.youtube.com/v/Y1I4tKYMLsE\\\">Full Screen</a> <a href=\\\"https://www.youtube.com/watch?v=Y1I4tKYMLsE\\\">Alternate</a></p><p class=\\\"Abstract\\\">Tissue processing: 19 sec <a href=\\\"https://www.youtube.com/v/7nYpxL2qPhg\\\">Full Screen</a> <a href=\\\"https://www.youtube.com/watch?v=7nYpxL2qPhg\\\">Alternate</a></p><p class=\\\"Abstract\\\">Section cutting: 33 sec <a href=\\\"https://www.youtube.com/v/_amFL9kNLBw\\\">Full Screen</a> <a href=\\\"https://www.youtube.com/watch?v=_amFL9kNLBw\\\">Alternate</a></p>\",\"PeriodicalId\":8719,\"journal\":{\"name\":\"Bangladesh Journal of Pharmacology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2018-08-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://sci-hub-pdf.com/10.3329/BJP.V13I3.35648\",\"citationCount\":\"4\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Bangladesh Journal of Pharmacology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.3329/BJP.V13I3.35648\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHARMACOLOGY & PHARMACY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Bangladesh Journal of Pharmacology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3329/BJP.V13I3.35648","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
Potential of Mimosa pudica leaf in the treatment of ulcerative colitis in rat
The aim of present investigation was to validate its folk use in the treatment of ulcerative colitis in the rat model. Sprague Dawley rats were divided into nine groups with six animals in each group. The rats received seven days of pretreatment with chloroform, ethyl acetate or ethanolic extract of Mimosa pudica. For induction of ulcerative colitis, rats were administered with 2 mL of 4% acetic acid solution intrarectally. Ulcer index, macroscopical study of the colon, myeloperoxidase and malondialdehyde levels in colon tissue and blood, and histopathology of the colon tissue were studied. Intrarectal instillation of acetic acid caused increased ulcer index, colonic myeloperoxidase and malondialdehyde. Pretreatment with M. pudica ethanolic extract (400 mg/kg) significantly lowered the ulcer index, colonic myeloperoxidase and malondialdehyde as compared with the standard drug prednisolone. The present investigation demonstrates that the ethanol extract of M. pudica leaf is effective in the treatment of ulcerative colitis.
期刊介绍：
Bangladesh Journal of Pharmacology (Bangladesh J Pharmacol) is an open access, video component, peer-reviewed journal of the Bangladesh Pharmacological Society (BDPS).
A scholarly publication is defined ''open access'' when there are no financial, legal or technical barriers to accessing it. Anyone can read, download, copy, distribute, print or use it in educational purpose within the legal agreements.
Peer review of a manuscript means the evaluation of research work by one or more people with similar competences. It can be open or blind. We do the single-blind peer review.
Our readers want to know the methodology used by the researchers which is very important to get the results. The video clip of one of the methodologies is prepared by the authors and submit it to publish.
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