Comparison of the Effects of Aprepitant and Ondansetron Individually and Combining on Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy

Background: Nausea and vomiting are one of the most common postoperative complications that cause unpleasant feelings and delays in the discharge of patients. This study aimed to compare the effect of aprepitant, ondansetron, and their combination on the severity of nausea and vomiting after this procedure for finding a safe and less indisposition regimen. Materials and methods: This study was performed on patients aged 18–50 who had been diagnosed with symptomatic cholelithiasis and who underwent laparoscopic cholecystectomy under general anesthesia. This study was done single-blinded. Patients were categorized into three groups (the recipient of aprepitant, the recipient of ondansetron, and the group receiving ondansetron and aprepitant simultaneously) and the rate of nausea and vomiting was measured at 6 and 24 hours after the operation. Results: The results of one-way analysis of variance analysis and Kruskal–Wallis showed that there was a significant difference between the treatment groups regarding the severity of nausea and vomiting after surgery ( p < 0.001). The severity of nausea and vomiting in the group receiving ondansetron plus aprepitant is less than the other two groups. Conclusion: A combination of ondansetron plus aprepitant can reduce nausea and vomiting after surgery while the effect of aprepitant is much more than ondansetron.