干细胞在癌症发生发展中的作用探讨

Q4 Medicine

Annals of Cancer Research and Therapy Pub Date : 2020-01-21 DOI:10.4993/acrt.28.3

A. Ebrahimi, P. Abbasi, M. Cucchiarini

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引用次数: 3

摘要

肿瘤包括两种类型的非癌细胞，第一种是募集细胞，如干细胞和巨噬细胞，第二种是组织稳定细胞，作为组织的一部分，包括脂肪细胞、成纤维细胞和稳定的巨噬细胞来源的细胞，它们都对肿瘤的进展有重要影响。本文综述了干细胞对癌症进展的一些影响，因为干细胞治疗对癌细胞系的主要结果揭示了有争议的结果。此外，本综述将探讨不同癌症反应的一些原因，并假设未折叠蛋白反应的概念是癌症发展的关键开关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Exploring the Role of Stem Cells in Cancer Development and Progression

Tumors comprise two types of non-cancerous cells, first recruited cells such as stem cells and macrophages, and second, tissue-steady cells that are part of the tissue including adipose cells, fibroblasts, and steady macrophage-derived cells, all having a significant impact on tumor progression. This review addresses some effects of stem cells on cancer advancement as the predominant outcome of stem cell therapy on cancer cell lines revealed controversial results. In addition, this review will address some reasons of distinct cancer responses and hypotheses the notion of unfolded protein response as a key switch in cancer development.

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来源期刊

Annals of Cancer Research and Therapy Medicine-Pharmacology (medical)

CiteScore

0.70

自引率

0.00%

发文量