黑胡桃皮40%乙醇提取物的神经保护作用

Q3 Pharmacology, Toxicology and Pharmaceutics
D. Pozdnyakov, Z. Dayronas, D. S. Zolotych, Anastasya D. Geraschenko, N. B. Shabanova
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引用次数: 0

摘要

引言:神经保护是缺血性脑损伤辅助治疗的一个很有前途的领域。同时,在潜在有效的神经保护剂中,草药疗法因其高效和安全的使用而与众不同。在这项工作中,某些方面的神经保护作用达到40%乙醇 对黑胡桃皮提取物及其主要成分进行了比较研究朱古龙. 材料和方法:以雄性Wistar大鼠为实验对象,采用不可逆性脑中动脉闭塞法模拟脑缺血。初步评价了提取物的急性毒性。在工作过程中,确定了以下参数:动物在Morris水迷宫中的行为变化、脑血流量、脑坏死区面积、线粒体复合物的活性、柠檬酸合成酶活性、乳酸、丙酮酸和ATP浓度。研究提取物的活性与朱古龙 浓度为1mg/kg(每os)。讨论:研究表明,在脑缺血条件下使用黑胡桃皮提取物有助于提高线粒体复合物I-V、柠檬酸合成酶的活性,从而使有氧厌氧代谢反应正常化。呼吸复合物活性的增加可能是由朱古龙, 它是黑胡桃皮试验提取物的主要成分。结论:因此,试验提取物可能是一种潜在有效的神经保护剂,需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Neuroprotective effects of a 40% ethanol extract of the black walnut bark (Juglans nigra L.)
Introduction: Neuroprotection is a promising area of adjuvant therapy of ischemic brain lesions. At the same time, among potentially effective neuroprotectors, herbal remedies are distinguished due to their high efficiency and safety of use. In this work, some aspects of the neuroprotective effect of 40% ethanol extract of black walnut bark were investigated in comparison with its major component juglone. Materials and methods: The work was performed on male Wistar rats, which were simulated with cerebral ischemia by irreversible occlusion of the middle cerebral artery. The acute toxicity of the extract was preliminarily evaluated. During the work, the following parameters were determined: changes in the behavior of animals in the Morris water maze, cerebral blood flow, brain necrosis zone area, the activity of mitochondrial complexes, citrate synthase activity, lactic, pyruvic, and ATP concentrations. The activity of the studied extract was compared with juglone in a concentration of 1 mg/kg (per os). Discussion: The study showed that the use of black walnut bark extract in conditions of cerebral ischemia contributed to an increase in the activity of mitochondrial complexes I-V, citrate synthase, which in turn led to the normalization of aerobic-anaerobic metabolism reactions. The increase in the activity of respiratory complexes is probably mediated by the antioxidant properties of juglone, which is a major component of the test extract of black walnut bark. Conclusion: Thus, the test extract can be a potentially effective neuroprotective agent and requires further study.
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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