50 ~ 70岁前列腺特异性抗原水平0 ~ 10 ng/mL未诊断前列腺癌男性血清前列腺特异性抗原水平与空腹血糖、总胆固醇及中性粒细胞淋巴细胞比值的关系

IF 0.1 Q4 ONCOLOGY
Bora Irer
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Differences between the groups in terms of serum PSA levels, serum total cholesterol, glucose, and NLR were analyzed. Results: The mean age of the participants was 60.2±5.4 years and the mean serum PSA level was 1.28±1.20 ng/mL. The mean PSA value was higher in the high cholesterol group (1.36±1.33 vs 1.19±1.02, p<0.001) compared to the low cholesterol group, and the mean PSA value in the high glucose group was lower than in the low glucose group (1.08±0.86 vs 1.32±1.25, p<0.001). Compared to the normal PSA group, the high PSA group had higher mean cholesterol level (208.6±39.9 vs 203.3±41.8, p<0.001) and NLR (2.17±1.00 vs 2.06±0.89, p=0.039), but lower glucose level (108.5±32.5 vs 117.2±51.0, p=0.004). Serum PSA level was positively correlated with total cholesterol and NLR (r=0.074 and p<0.001, r=0.050 and p=0.011), and negatively with glucose level (r=-0.084 and p<0.001). 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引用次数: 0

摘要

目的:探讨无前列腺癌男性血清前列腺特异性抗原(PSA)水平与总胆固醇、空腹血糖、中性淋巴细胞比值(NLR)的关系。材料与方法:2010年至2017年,在İzmir区村庄的İzmir大都会市e refpa医院进行的健康筛查项目中,从4643名健康男性中纳入2631名年龄在50-70岁,血清PSA水平为0-10 ng/mL的男性参与者。回顾性评估参与者的血清PSA、空腹血糖、总胆固醇水平和NLR。参与者按血清PSA水平高低、血糖水平高低、胆固醇水平高低进行分组。分析两组间血清PSA水平、血清总胆固醇、葡萄糖和NLR的差异。结果:参与者平均年龄为60.2±5.4岁,平均血清PSA水平为1.28±1.20 ng/mL。高胆固醇组PSA均值高于低胆固醇组(1.36±1.33 vs 1.19±1.02,p<0.001),高糖组PSA均值低于低糖组(1.08±0.86 vs 1.32±1.25,p<0.001)。与正常PSA组相比,高PSA组的平均胆固醇水平(208.6±39.9 vs 203.3±41.8,p<0.001)和NLR(2.17±1.00 vs 2.06±0.89,p=0.039)较高,血糖水平(108.5±32.5 vs 117.2±51.0,p=0.004)较低。血清PSA水平与总胆固醇和NLR呈正相关(r=0.074, p<0.001; r=0.050, p=0.011),与葡萄糖水平呈负相关(r=-0.084, p<0.001)。结论:评估总胆固醇、空腹血糖和NLR可能与血清PSA水平相关,这可能有助于泌尿科医生调查50-70岁未诊断为前列腺癌的无症状男性血清PSA水平升高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Assessment of the Relationship Between Serum Prostate-Specific Antigen Level and Serum Fasting Glucose, Total Cholesterol and Neutrophil-Lymphocyte Ratio in Men Aged 50-70 Years with Prostate-Specific Antigen Level 0-10 ng/mL without Prostate Cancer Diagnosis
Objective: To evaluate the relationship between serum prostate-specific antigen (PSA) level and total cholesterol, fasting blood glucose, and neutrophillymphocyte ratio (NLR) in men without prostate cancer. Materials and Methods: Between 2010 and 2017, 2631 male participants aged 50-70 years with a serum PSA level of 0-10 ng/mL were included from a population of 4643 healthy males who participated in a health screening program conducted by the İzmir Metropolitan Municipality Eşrefpaşa Hospital in the district villages of İzmir. Participants’ serum PSA, fasting blood glucose, total cholesterol levels, and NLR were retrospectively assessed. Participants were grouped as those with high and low serum PSA levels, high and low glucose levels, and high and low cholesterol levels. Differences between the groups in terms of serum PSA levels, serum total cholesterol, glucose, and NLR were analyzed. Results: The mean age of the participants was 60.2±5.4 years and the mean serum PSA level was 1.28±1.20 ng/mL. The mean PSA value was higher in the high cholesterol group (1.36±1.33 vs 1.19±1.02, p<0.001) compared to the low cholesterol group, and the mean PSA value in the high glucose group was lower than in the low glucose group (1.08±0.86 vs 1.32±1.25, p<0.001). Compared to the normal PSA group, the high PSA group had higher mean cholesterol level (208.6±39.9 vs 203.3±41.8, p<0.001) and NLR (2.17±1.00 vs 2.06±0.89, p=0.039), but lower glucose level (108.5±32.5 vs 117.2±51.0, p=0.004). Serum PSA level was positively correlated with total cholesterol and NLR (r=0.074 and p<0.001, r=0.050 and p=0.011), and negatively with glucose level (r=-0.084 and p<0.001). Conclusion: Evaluation of total cholesterol, fasting glucose, and NLR, which may be associated with serum PSA levels, may help urologists when investigating elevated serum PSA levels in asymptomatic men aged 50-70 years who have not been diagnosed with prostate cancer.
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