LncRNA XIST在妇科肿瘤中的作用

IF 0.4 Q4 ONCOLOGY

Current Cancer Therapy Reviews Pub Date : 2023-01-02 DOI:10.2174/1573394719666230102124549

M. Farzaneh, R. Jafari, Ali Tahan, Mohammad Amin Askari, Hasti Roshandel, Seyed Mohammad Ali Gharizadeh

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引用次数: 0

摘要

长链非编码rna (lncrna)是长度超过200个核苷酸的非编码rna，其作用是靶向翻译和翻译后修饰、表观遗传调控因子和染色质重塑复合物。越来越多的证据表明，lncRNA x无活性特异性转录物(lncRNA Xist)通过靶向mirna和转录因子在细胞生长、增殖和分化中起着至关重要的作用。该lncRNA作为竞争内源性RNA (ceRNA)在肿瘤和其他人类疾病的进展中也发挥重要作用。越来越多的证据表明lncRNA Xist通过靶向多种信号通路参与妇科肿瘤的发病过程。在这篇综述中，我们主要关注lncRNA Xist在乳腺癌、宫颈癌和卵巢癌中的最新功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Role of LncRNA XIST in Gynecologic Cancers

Long non-coding RNAs (lncRNAs) are non-coding RNAs longer than 200 nucleotides that act by targeting translational and post-translational modifications, epigenetic regulators, and chromatin remodeling complexes. There has been increasing evidence that the lncRNA X-inactive specific transcript (lncRNA Xist) via targeting miRNAs and transcription factors plays a critical role in cell growth, proliferation, and differentiation. This lncRNA also has an important role in the progression of tumors and other human diseases by acting as a competing endogenous RNA (ceRNA). Accumulating evidence revealed that lncRNA Xist by targeting several signaling pathways is involved in the pathogenesis of gynecologic cancers. In this review, we focused on the recent functions of lncRNA Xist in breast, cervical, and ovarian cancers.

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来源期刊

Current Cancer Therapy Reviews ONCOLOGY-

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： Current Cancer Therapy Reviews publishes frontier reviews on all the latest advances in clinical oncology, cancer therapy and pharmacology. The journal"s aim is to publish the highest quality review articles dedicated to clinical research in the field. The journal is essential reading for all researchers and clinicians in cancer therapy.