基于Genbank NCBI的严重急性呼吸系统综合征冠状病毒2型核糖核酸Silico序列系统发育构建的新冠病毒19的分布

Q3 Multidisciplinary

Walailak Journal of Science and Technology Pub Date : 2020-08-30 DOI:10.48048/wjst.2020.9814

R. Mege, H. Sumampouw, D. N. Oka, N. Manampiring, Y. Mokosuli

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引用次数: 1

摘要

由严重急性呼吸道冠状病毒（SARS-CoV-2）病毒引起的新冠肺炎大流行对当今人类文明产生了影响，本研究旨在利用NCBI GenBank的SARS新冠肺炎基因数据库，构建世界各国导致Covid-19]的SARS冠状病毒的系统发育，以及这些基因与世界各国的进化关系本研究使用来自NCBI GenBank（www.NCBI-nih.gov）的基因序列来源的计算机方法。截至4月2日，21个国家共报告了433个SARS新冠肺炎序列，2020年是研究的主题。使用MEGA 70程序分析了代表每个国家的序列。结果表明，形成的系统发育树由2个主要单系群获得。第一个主要单系统群由11个节点组成，来自23个国家的19个SARS-CoV-2基因序列。第二个主要单系群由5个节点组成，5个国家为SARS-CoV序列的起源国，中国向世界的迁移是随机发生的。这是因为中国震中的人口迁移。与中国相邻的国家的位置并不能确定最接近的系统发育关系。形成的系统发育节点的数量显示出突变，导致严重急性呼吸系统综合征冠状病毒2型核糖核酸基因序列的高度变异。这项研究的结果强化了必须努力限制人类病毒向人类传播。来自中国的两个主要单系群序列的存在证实了这种病毒起源于中国的震中©2020，瓦伊拉克大学保留所有权利

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The Distribution of COVID 19 based on Phylogeny Construction in Silico Sequences SARS-CoV-2 RNA at Genbank NCBI

The Covid-19 pandemic, due to severe acute respiratory coronavirus (SARS-CoV-2) virus, has an effect on human civilization today With high fatality infections, SARS Covid-19 has influenced the global economic, socio-cultural, and even political order This study aims to construct the phylogeny of the SARS corona virus that causes Covid-19 in various countries in the world by using the SARS Covid-19 gene database from the NCBI GenBank The results of this study can trace the origin of SARS Covid-19, which is then called SARS-CoV-2, the gene characteristics, and the evolutionary relationship of these genes to various countries in the world This research uses in silico method with gene sequence sources from the NCBI GenBank (www ncbi nih gov) A total of 433 SARS Covid-19 sequences reported by 21 countries as of April 2rd, 2020 were the subject of the study Sequences representing each country were analyzed using the MEGA 7 0 program The results showed that the phylogeny trees formed were obtained by 2 main monophyletic groups The first major monophyletic group consisted of 11 nodes, with 19 SARS-CoV-2 gene sequences from 23 countries The second major monophyletic group consisted of 5 nodes with 5 countries of origin of SARS-CoV sequence 19 The spread of Covid-19 from the epicenter in Wuhan, China to the world has taken place randomly This has happened because of the migration of people from the Chinese epicenter The location of the countries adjacent to China did not determine the closest phylogenic relationship The number of phylogenetic nodes formed showed mutases which caused very high variations of the SARS CoV 2 RNA gene sequence The results of this study reinforce that efforts to limit the spread of human viruses to humans must be done The presence of sequences from China in the 2 main monophyletic groups confirms that this virus originated in the Chinese epicenter © 2020, Walailak University All rights reserved

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来源期刊

Walailak Journal of Science and Technology Multidisciplinary-Multidisciplinary

CiteScore

0.80

自引率

0.00%

发文量

审稿时长

24 weeks

期刊介绍： The Walailak Journal of Science and Technology (Walailak J. Sci. & Tech. or WJST), is a peer-reviewed journal covering all areas of science and technology, launched in 2004. It is published 12 Issues (Monthly) by the Institute of Research and Innovation of Walailak University. The scope of the journal includes the following areas of research : - Natural Sciences: Biochemistry, Chemical Engineering, Chemistry, Materials Science, Mathematics, Molecular Biology, Physics and Astronomy. -Life Sciences: Allied Health Sciences, Biomedical Sciences, Dentistry, Genetics, Immunology and Microbiology, Medicine, Neuroscience, Nursing, Pharmaceutics, Psychology, Public Health, Tropical Medicine, Veterinary. -Applied Sciences: Agricultural, Aquaculture, Biotechnology, Computer Science, Cybernetics, Earth and Planetary, Energy, Engineering, Environmental, Food Science, Information Technology, Meat Science, Nanotechnology, Plant Sciences, Systemics