姜黄和圆柏乙醇提取物对MCF-7癌细胞的抗氧化和细胞毒性作用

T. Sundram, M. Zakaria, Mohd Hamzah Mohd Nasir
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引用次数: 6

摘要

姜科姜黄(Curcuma mangga)和姜黄(Bosenbergia rotunda)主要分布在包括马来西亚在内的东南亚国家。传统上,这些植物被用来治疗各种疾病。本文主要研究了芒草和圆藤乙醇提取物的抗氧化活性和细胞毒活性。本研究首先采用索氏提取法提取芒草根状茎和圆叶根状茎的乙醇提取物。芒草粗提物的总提取率为12.6%,圆形草粗提物的总提取率为3.5%。MTT法的IC50值分别为207µg/ml和31.96µg/ml。DPPH法测定芒草的抗氧化活性,其IC50值为1073µg/ml,高于圆形草(578µg/ml)。结果表明,两种提取物对MCF-7癌细胞生长和DPPH自由基活性均有较低的抑制作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
ANTIOXIDANT AND CYTOTOXIC EFFECTS OF CURCUMA MANGGA AND BOSENBERGIA ROTUNDA ETHANOLIC EXTRACTS ON MCF-7 CANCER CELL LINES
Curcuma mangga and Bosenbergia rotunda which belongs to Zingiberaceae family are largely distributed in South East Asian countries including Malaysia. These plants have been traditionally used for treatment of various diseases. In this research we focused on determining the antioxidant and cytotoxic activity of C. mangga and B. rotunda ethanolic extracts. Initially, in this study, ethanolic extracts from rhizomes of C. mangga and B. rotunda were obtained through Soxhlet extraction method. 12.6% and 3.5% of crude extract were obtained from C. mangga and B. rotunda respectively. For MTT assay, the IC50 values are 207µg/ml and 31.96 µg/ml for C. mangga and B. rotunda respectively. Meanwhile for the antioxidant activity using DPPH assay, C. mangga showed higher antioxidant activity with IC50 values of 1073µg/ml compared to B. rotunda with IC50 values of 578µg/ml. It can be concluded both extracts showed low inhibitory effect on MCF-7 cancer cells growth and DPPH free radical activity.
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