基于7-羟基-6-甲酰基(乙酰基)色酮的线性杂芳烃色酮的合成

IF 0.4 Q4 CHEMISTRY, ANALYTICAL
Tatyana Shokol, N. Gorbulenko, Khilya Volodymyr
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引用次数: 0

摘要

融合色素因其广泛分布、有效的生物活性和低毒性等优点,作为一种新型的治疗药物越来越受到人们的关注。6-羰基-7-羟色胺被证明是一种多用途的合成子,可以通过杂环环化到色胺核心来合成线性的异色胺。本文综述了呋喃[3,2-g]铬、吡喃[3,2-g]铬及其含n类似物,即[6,7-d]异恶唑、吡喃[3 ',2 ':6,7]吡啶- 4,3-b -5,11-二酮和吡喃[3 ',2 ':6,7]吡啶-5,11-二酮在7-羟基-6-甲酰基或7-羟基-6-乙酰基铬基础上的合成,并介绍了迄今为止的研究现状。本文还介绍了起始型7-羟基-6-甲酰色胺酮和7-羟基-6-乙酰色胺酮的合成方法。天然存在的和修饰的合成线性异肾上腺素的生物活性也被描述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Synthesis of linear hetarenochromones based on 7-hydroxy-6-formyl(acetyl)chromones
Fused chromones are attracting increasing attention as novel therapeutic agents due to their wide distribution in nature, effective bioactivities and low toxicity. 6-Carbonyl-7-hydroxychromones proved to be versatile synthons for the synthesis of linear hetarenochromones by annulation of heterocycle to the chromone core. The present review is focused on the syntheses of furo[3,2-g]chromones, pyrano[3,2-g]chromones and some of their N-containing analogues, namely chromeno[6,7-d]isoxazoles, pyrano[3’,2’:6,7]chromeno[4,3-b]pyridine-5,11-diones and pyrano[3’,2’:6,7]chromeno[4,3-c]pyridine-5,11-diones based on the 7-hydroxy-6-formylchromones or 7-hydroxy-6-acetylchromones and shows the current state of research to date. The methods for the synthesis of the starting 7-hydroxy-6-formylchromones and 7-hydroxy-6-acetylchromones have been also mentioned. The biological activity of naturally occurring and modified synthetic linear hetarenochromones has been also represented.
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来源期刊
French-Ukrainian Journal of Chemistry
French-Ukrainian Journal of Chemistry CHEMISTRY, ANALYTICAL-
自引率
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发文量
13
审稿时长
4 weeks
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