p120 - Catenin在口腔鳞状细胞癌及口腔鳞状细胞癌旁正常黏膜中的表达

A. Rajeev, Karishma M Desai, Ramyani Sinha, Pallavi Saxena, K. Saikumar
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引用次数: 0

摘要

大多数HNC病例和死亡都是由于与某些遗传特征相关的个体易感性和生活方式行为(吸烟和饮酒),其次是与人乳头瘤病毒(HPV)有关。致癌过程中可能导致恶性转化倾向的侵袭和迁移的一个重要分子事件是细胞粘附(如p120连环蛋白)的改变。p120连环蛋白(p120)的缺失和/或其磷酸化导致E-钙粘蛋白的不稳定;因此,它调节钙粘蛋白的稳定性和周转,从而影响细胞的粘附性和迁移能力。因此,本综述将详细介绍p120与各种人类上皮多种肿瘤类型(包括OSCCs)的侵袭性和进展有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Expression of p120 – Catenin in oral squamous cell carcinoma and apparently normal mucosa adjacent to oral squamous cell carcinoma
Most HNC cases and deaths are due to both individual predispositions linked to certain genetic characteristics, and lifestyle behaviors (tobacco and alcohol use) and secondary is an association with human papillomavirus (HPV). One of the important molecular event in carcinogenesis that could result in invasion and migration predisposing to malignant transformation is alteration in the cell adhesion such as p120 catenin. The loss of p120 catenin (p120) and/or its phosphorylation causes destabilization of E-cadherin; thus, it regulates cadherin stability and turnover which affects the cell adhesiveness and migratory capacity. Therefore, the present review will give the details of p120 is linked to the invasiveness and progression of various human epithelial many tumor types, including OSCCs.
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