一名无已知合并症患者接种ChAdOx1-nCoV-19冠状病毒疫苗后的吞噬细胞性淋巴组织细胞增多症

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL

Indian Journal of Medical Specialities Pub Date : 2022-10-01 DOI:10.4103/injms.injms_80_22

N. Rai, S. Misra, Shashank Prajapati, Shubhajeet Roy, G. Yadav

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引用次数: 0

摘要

噬血细胞淋巴组织细胞病(HLH)是一种炎症性疾病，其特征是细胞明显减少，巨噬细胞和CD8+细胞毒性T细胞大规模活化。HLH可能有两种类型——由遗传异常引起的原发性HLH和由感染、恶性肿瘤、自身免疫性疾病、风湿病和代谢功能障碍引起的继发性HLH。我们报告一例在首次接种ChAdOx1 nCoV-19冠状病毒疫苗后发生的HLH病例。在这个病人中，没有明显的HLH沉淀。最可能的解释可能是疫苗成分产生炎症细胞因子异常激活的强烈免疫激活。没有感染或恶性肿瘤的迹象。由于我们的患者临床稳定，他的症状已经缓解，并且HLH参数有所改善，因此没有给予HLH特异性治疗。

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Hemophagocytic lymphohistiocytosis after ChAdOx1 nCoV-19 coronavirus vaccination in a patient with no known comorbidities

Hemophagocytic lymphohistiocytosis (HLH) is an inflammatory condition where there is marked cytopenia and large-scale activation of macrophages and CD8+ cytotoxic T cells. HLH may be of two types – primary HLH caused by genetic abnormalities and secondary HLH due to infections, malignancies, autoimmune disorders, rheumatologic disorders, and metabolic dysfunctions. We describe a case of HLH following the first dose of the ChAdOx1 nCoV-19 Corona Virus vaccine. In this patient, there was no clear precipitant of HLH. The most probable explanation could be intense immune activation by vaccine constituents producing aberrant activation of inflammatory cytokines. There were no signs of infection or malignancy. Since our patient was clinically stable, his symptoms had resolved and HLH parameters had improved, no HLH-specific therapy was given.

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来源期刊

Indian Journal of Medical Specialities MEDICINE, GENERAL & INTERNAL-

自引率

16.70%

发文量

期刊介绍： The Indian Journal of Medical Specialities is an all-encompassing peer-reviewed quarterly journal. The journal publishes scholarly articles, reviews, case reports and original research papers from medical specialities specially pertaining to clinical patterns and epidemiological profile of diseases. An important highlight is the emphasis on undergraduate and postgraduate medical education including various aspects of scientific paper-writing. The journal gives priority to research originating from the developing world, including from the tropical regions of the world. The journal also publishes special issues on health topics of current interest. The Indian Journal of Medical Specialities is one of the very few quality multispeciality scientific medical journals.