临床1型神经纤维瘤病患者转移性癌症

IF 0.2 Q4 ONCOLOGY
Elīna Nadziņa , Evita Gašenko , Signe Plāte , Žanete Zvirbule , Alinta Hegmane
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引用次数: 0

摘要

神经纤维瘤患者患相关癌症的风险高,需要专门的癌症筛查指南1。然而,对于大多数这些癌症类型的早期检测方法目前还不存在。对于某些癌症类型,如乳腺癌,可以进行筛查,重要的是要注意,这一患者群体患乳腺癌的风险增加,并且可能比一般人群更早出现。在此,我们报告一例48岁女性,临床诊断为1型神经纤维瘤,表现为左乳多发皮肤神经纤维瘤之间皮肤颜色改变,瘙痒和硬结。她被诊断为IV期HER2阳性乳腺癌,伴有肝脏和双侧腋窝淋巴结转移,接受化疗和抗HER2抗体治疗。CT扫描也描述了结构性肺实质改变和脊柱侧凸。本案例研究的目的是强调神经纤维瘤患者教育的必要性,鼓励他们在出现新症状时立即寻求建议,并提示医疗提供者对该患者组使用额外的谨慎。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Metastatic breast cancer in patient with clinical neurofibromatosis type 1

Patients with neurofibromathosis have a high risk of associated cancers and specialized cancer screening guidelines1. However for most of these cancer types early detection methods currently do not exist. For some cancer types, such as breast cancer, where screening is available, it is important to note that this patient group has increased risk of breast cancer and may present at an earlier age than general population.

Here, we describe a case of 48-year-old female with clinical diagnosis of neurofibromathosis type 1, who presented with skin color changes, itching and induration in left breast between multiple skin neurofibromas. She was diagnosed with stage IV HER2 positive breast cancer with hepatic and bilateral axillary lymph node metastasis, treated with chemotherapy and anti-HER2 antibodies. CT scan also described structural lung parenchyma alterations and scoliosis.

The aim of this case study is to emphasize the need of neurofibromathosis patient education in encouraging them to seek advice as soon as new symptoms appear and to prompt medical providers to use additional caution in this patient group.

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CiteScore
0.40
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