Mitochondrial cristae: lung cancer metabolism architects

In a recent study published in Nature, Shackelford and colleagues use an innovative in vivo mitochondrial morphology and bioenergetics analysis pipeline to correlate the metabolic signature of non-small cell lung cancer subtypes to the ultrastructure of mitochondria and their contact sites with lipid droplets. This study paves the way for diagnostic and therapeutic protocols for lung cancer based on the rationale assessment and modulation of mitochondrial topology and ultrastructure.